SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
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A genome stability regulator integrates DNA repair and stress signaling pathways.
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SIRT6 promotes DNA double strand break repair, regulates telomere stability, suppresses inflammation and opposes tumorigenesis.
“SIRT6 promotes DNA double strand break repair19,20, regulates telomere stability21, suppresses inflammation22 and opposes tumorigenesis23,24.”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [19]
SIRT6 has multiple biochemical activities, including protein deacetylation and mono-ADP ribosylation.
“SIRT6 has multiple biochemical activities, including protein deacetylation22 and mono-ADP ribosylation19,29.”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [19]
SIRT6 rapidly relocalizes to DNA damage sites in response to oxidative stress.
“SIRT6 is known to rapidly relocalize to DNA damage sites in response to oxidative stress19,36.”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [19]
SIRT6 has been reported to mono-ADP ribosylate PARP1.
“SIRT6 has been reported to mono-ADP ribosylate PARP119”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [19]
In vitro mono-ADP ribosylation experiments were conducted essentially as previously described.
“In vitro mono-ADP ribosylation experiments were conducted essentially as previously described19.”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [19]
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- Authors
- Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., & Gorbunova, V.
- Affiliations
- University of Rochester (US)
- Department of Biology, University of Rochester, Rochester, NY 14627, USA.
- Corresponding author
- Seluanov, Andrei
- Gorbunova, Vera
- Venue
- Science
- Published
- 2011-06-17
- Volume
- 332
- Issue
- 6036
- Pages
- 1443-1446
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5472447
- OpenAlex
- W2054866841
- Cited by
- 867
- References
- 5
- Citations by year
- 2026: 39 · 2025: 47 · 2024: 49 · 2023: 68 · 2022: 47 · 2021: 72 · 2020: 64 · 2019: 55 · 2018: 50 · 2017: 65 · 2016: 70 · 2015: 54 · 2014: 57 · 2013: 61 · 2012: 57
- FWCI
- 24.30
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (F31AG041603, R01AG027237)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- SIRT6, PARP1, DNA double-strand break repair, oxidative stress, mono-ADP-ribosylation, non-homologous end joining, homologous recombination, genomic instability, sirtuins, ADP-ribosyltransferase activity
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Animals, Cell Line, DNA, DNA Repair, Humans, Paraquat, Poly Adenosine Diphosphate Ribose, Poly(ADP-ribose) Polymerases, Recombination, Genetic, Transfection, Signal Transduction, Point Mutation, Mice, Knockout, Oxidative Stress, Sirtuins, Mice, DNA Breaks, Double-Stranded
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