The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Copy number alteration burden predicts prostate cancer relapse
Open accessAbstract
Significance: Prostate cancer is a major health burden with significant overtreatment because of difficulty segregating high- and low-risk disease. Discovery of biomarkers that stratify risk could have a broad public health impact but requires cohorts with comprehensive molecular and clinical follow-up. We characterize two independent prostate cancer cohorts with genomic and clinical data that include biochemical recurrence and metastasis. We demonstrate that copy number alteration (CNA) burden, a measure of the fraction of a tumor genome that is copy number altered, is prognostic for recurrence and metastasis. CNA burden is also associated with cancer recurrence in an intermediate risk population, and can be identified in biopsies. This work provides a clinicogenomic resource and highlights oncogenomics' potential to identify needed prognostic factors.
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Cites
Integrative Genomic Profiling of Human Prostate Cancer
Taylor, B. S., Schultz, N., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E., Reva, B., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,701
Self-citationFrampton, G. M., Fichtenholtz, A., Otto, G. A., Wang, K., Downing, S. R., He, J., Schnall-Levin, M., White, J., Sanford, E. M., An, P., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2696 · Cited by 2,157 · cited 1×
“As we have shown that CNA burden can be successfully determined in formalin-fixed needle biopsies, future work may explore CNA burden within large biopsy cohorts to determine its prognostic power (29, 30).”
BackgroundRadical Prostatectomy versus Watchful Waiting in Early Prostate Cancer
Bill-Axelson, A., Holmberg, L., Ruutu, M., Garmo, H., Stark, J. R., Busch, C., Nordling, S., Häggman, M., Andersson, S.-O., Bratell, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011967 · Cited by 1,900
Radical Prostatectomy versus Observation for Localized Prostate Cancer
Wilt, T. J., Brawer, M. K., Jones, K. M., Barry, M. J., Aronson, W. J., Fox, S., Gingrich, J. R., Wei, J. T., Gilhooly, P., Grob, B. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113162 · Cited by 1,770
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
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Stephenson, A. J., Scardino, P. T., Eastham, J. A., Bianco, F. J., Dotan, Z. A., DiBlasio, C. J., Reuther, A., Klein, E. A., & Kattan, M. W. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.867 · Cited by 663
Self-citationErho, N., Crisan, A., Vergara, I. A., Mitra, A. P., Ghadessi, M., Buerki, C., Bergstralh, E. J., Kollmeyer, T., Fink, S., Haddad, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066855 · Cited by 644
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Cited by
Integrative Clinical Genomics of Advanced Prostate Cancer
Robinson, D., Van Allen, E. M., Wu, Y.-M., Schultz, N., Lonigro, R. J., Mosquera, J.-M., Montgomery, B., Taplin, M.-E., Pritchard, C. C., Attard, G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.001 · Cited by 3,645
“…additional alterations in AR (Taplin et al., 1995) and in the androgen signaling pathway (Beltran et al., 2013; Grasso et al., 2012; Gundem et al., 2015; Hong et al., 2015), although these studies were performed predominantly using autopsy samples or preclinical models with limited cohort sizes.”
Self-citationThe Molecular Taxonomy of Primary Prostate Cancer
Abeshouse, A., Ahn, J., Akbani, R., Ally, A., Amin, S., Andry, C. D., Annala, M., Aprikian, A., Armenia, J., Arora, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.025 · Cited by 3,110
Self-citationPersonalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine
Pauli, C., Hopkins, B. D., Prandi, D., Shaw, R., Fedrizzi, T., Sboner, A., Sailer, V., Augello, M., Puca, L., Rosati, R., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1154 · Cited by 937
The long tail of oncogenic drivers in prostate cancer
PCF/SU2C International Prostate Cancer Dream Team, Armenia, J., Wankowicz, S. A. M., Liu, D., Gao, J., Kundra, R., Reznik, E., Chatila, W. K., Chakravarty, D., Han, G. C., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0078-z · Cited by 867
Self-citationMolecular landmarks of tumor hypoxia across cancer types
Bhandari, V., Hoey, C., Liu, L. Y., Lalonde, E., Ray, J., Livingstone, J., Lesurf, R., Shiah, Y.-J., Vujcic, T., Huang, X., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0318-2 · Cited by 678
Metadata
- Authors
- Hieronymus, H., Schultz, N., Gopalan, A., Carver, B. S., Chang, M. T., Xiao, Y., Heguy, A., Huberman, K., Bernstein, M., Assel, M., Murali, R., Vickers, A., Scardino, P. T., Sander, C., Reuter, V., Taylor, B. S., & Sawyers, C. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-07-14
- Volume
- 111
- Issue
- 30
- Pages
- 11139-11144
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038120654
- Cited by
- 364
- References
- 27
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Hieronymus, H., Schultz, N., Gopalan, A., Carver, B. S., Chang, M. T., Xiao, Y., Heguy, A., Huberman, K., Bernstein, M., Assel, M., Murali, R., Vickers, A., Scardino, P. T., Sander, C., Reuter, V., Taylor, B. S., & Sawyers, C. L. (2014). Copy number alteration burden predicts prostate cancer relapse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1411446111
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