The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
Open accessAbstract
Significance: Despite the high antigenic diversity of the HIV envelope trimer (Env), broadly neutralizing antibodies (bnAbs) have identified conserved regions that serve as targets for vaccine design. One of these regions is located at the apex of Env and is expressed fully only in the context of the correctly folded trimer. This work describes the isolation of bnAbs that target this region using a recombinant native-like Env trimer as an affinity reagent to sort specific antibody-producing cells. Characterization of these antibodies reveals a highly diverse antibody response against the trimer apex and provides molecular information that will be useful in the design of immunogens to elicit bnAbs to this region of Env.
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Cited by
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Metadata
- Authors
- Sok, D., van Gils, M. J., Pauthner, M., Julien, J.-P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., Moore, J. P., Ward, A. B., Wilson, I. A., Sanders, R. W., & Burton, D. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-11-24
- Volume
- 111
- Issue
- 49
- Pages
- 17624-17629
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066082644
- Cited by
- 364
- References
- 43
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sok, D., van Gils, M. J., Pauthner, M., Julien, J.-P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., Moore, J. P., Ward, A. B., Wilson, I. A., Sanders, R. W., & Burton, D. R. (2014). Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1415789111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
