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Cited by 485Effects and risks of endocrine disrupting chemicalsReproductive biology and impacts on aquatic speciesZebrafish Biomedical Research Applications

Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish

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Kinch, Cassandra D., Ibhazehiebo, Kingsley, Jeong, Joo-Hyun, Habibi, Hamid R., Kurrasch, Deborah M.·2015·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1417731112PMC PMC4321238
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Abstract

Significance: Here we demonstrate that bisphenol A (BPA) exposure during a time point analogous to the second trimester in humans has real and measurable effects on brain development and behavior. Furthermore, our study is the first, to our knowledge, to show that bisphenol S, a replacement used in BPA-free products, equally affects neurodevelopment. These findings suggest that BPA-free products are not necessarily safe and support a societal push to remove all structurally similar bisphenol analogues and other compounds with endocrine-disruptive activity from consumer goods. Our data here, combined with over a dozen physiological and behavioral human studies that begin to point to the prenatal period as a BPA window of vulnerability, suggest that pregnant mothers limit exposure to plastics and receipts.

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  • Linkages between developmental BPA exposure and an anxiogenic phenotype have repeatedly been shown in dozens of studies using a variety of animal models and human populations.

    “Nevertheless, linkages between developmental BPA exposure and an anxiogenic phenotype have repeatedly been shown in dozens of studies using a variety of animal models and human populations (representative examples include (62, 91, 93, 96–100)).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [91]

    The section “BPA Exposure During Hypothalamic Neurogenesis Induces Hyperactivity” (page unavailable) reports increased locomotor activity after embryonic BPA exposure in zebrafish and says such bursts can indicate anxiety-like behavior. The paper also discusses possible links between prenatal BPA exposure and behavioral outcomes in humans, while noting mixed results. It does not establish an anxiogenic phenotype repeatedly shown in dozens of studies across animal models and human populations. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Exposure to BPA and BPS in zebrafish led to premature hypothalamic neurogenesis even at low doses.

    “In experimental studies, exposure to BPA and BPS in zebrafish led to premature hypothalamic neurogenesis even at low doses (Kinch et al., 2015; Walker and Gore, 2017).”

    From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Kinch et al., 2015

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Cited by

Sorted by citations

Authors
Kinch, C. D., Ibhazehiebo, K., Jeong, J.-H., Habibi, H. R., & Kurrasch, D. M.
Affiliations
  • University of Calgary (CA)
  • Departments of aBiological Sciences and
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2015-01-12
Volume
112
Issue
5
Pages
1475-1480
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1417731112
PMC
PMC4321238
OpenAlex
W1977710838
Cited by
485
References
4
Citations by year
2026: 28 · 2025: 32 · 2024: 27 · 2023: 36 · 2022: 29 · 2021: 48 · 2020: 52 · 2019: 60 · 2018: 59 · 2017: 52 · 2016: 42 · 2015: 19
FWCI
35.96
Type
journal article
Language
en
Open access
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (DG35868, RGPIN 156910, PGSD2-459881-2014)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Keywords
bisphenol A, bisphenol S, endocrine disruptors, hypothalamic neurogenesis, hyperactivity, neurodevelopmental disorders, androgen receptor, aromatase, low-dose exposure, zebrafish embryos
MeSH terms
Bisphenol A Compounds, Bisphenol S Compounds, Animals, Behavior, Animal, Benzhydryl Compounds, Dose-Response Relationship, Drug, Humans, Hypothalamus, Phenols, Sulfones, Zebrafish, Neurogenesis

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