Cited by 332Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactHealth, Environment, Cognitive Aging

Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort

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Perera, Frederica, Vishnevetsky, Julia, Herbstman, Julie B, Calafat, Antonia M, Xiong, Wei, Rauh, Virginia, Wang, Shuang·2012·Environmental Health Perspectives

Abstract

Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior. Objective: We examined the association between prenatal BPA exposure and child behavior, adjusting for postnatal BPA exposure and hypothesizing sex-specific effects. Methods: We followed African-American and Dominican women and their children from pregnancy to child’s age 5 years, collecting spot urine samples from the mothers during pregnancy (34 weeks on average) and from children between 3 and 4 years of age to estimate BPA exposure. We assessed child behavior between 3 and 5 years of age using the Child Behavior Checklist (CBCL) and used generalized linear models to test the association between BPA exposure and child behavior, adjusting for potential confounders. Results: The analysis was conducted on 198 children (87 boys and 111 girls). Among boys, high prenatal BPA exposure (highest quartile vs. the lowest three quartiles) was associated with significantly higher CBCL scores (more problems) on Emotionally Reactive [1.62 times greater; 95% confidence interval (CI): 1.13, 2.32] and Aggressive Behavior syndromes (1.29 times greater; 95% CI: 1.09, 1.53). Among girls, higher exposure was associated with lower scores on all syndromes, reaching statistical significance for Anxious/Depressed (0.75 times as high; 95% CI: 0.57, 0.99) and Aggressive Behavior (0.82 times as high; 95% CI: 0.70, 0.97). Conclusion: These results suggest that prenatal exposure to BPA may affect child behavior, and differently among boys and girls.

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  • In a cohort of 198 children ages 3-5, high levels of maternal BPA were associated with altered emotional reactivity including increased aggressive behavior in boys.

    “In a cohort of 198 children ages 3–5, high levels of maternal BPA were associated with altered emotional reactivity including increased aggressive behavior in boys [ 136 ].”
  • These boys at 3-5 years of age displayed increased aggressive behavior and their emotionally reactive symptom scores were 1.62 times higher compared with boys with low prenatal BPA concentrations.

    “Intriguingly, these boys at 3–5 years of age displayed increased aggressive behavior and their emotionally reactive symptom scores were 1.62 times higher compared with boys with low prenatal BPA concentrations [ 136 ].”

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Authors
Perera, F., Vishnevetsky, J., Herbstman, J. B., Calafat, A. M., Xiong, W., Rauh, V., & Wang, S.
Affiliations
  • Columbia University (US)
  • Centers for Disease Control and Prevention (US)
Corresponding author
Perera, Frederica
Venue
Environmental Health Perspectives
Published
2012-04-27
Volume
120
Issue
8
Pages
1190-1194
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
OpenAlex
W2059905660
Cited by
332
References
40
Citations by year
2026: 4 · 2025: 13 · 2024: 20 · 2023: 14 · 2022: 14 · 2021: 22 · 2020: 55 · 2019: 24 · 2018: 24 · 2017: 35 · 2016: 22 · 2015: 38 · 2014: 17 · 2013: 26 · 2012: 3
FWCI
18.55
Type
journal article
Language
en
Open access
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Funders
  • U.S. Environmental Protection Agency (P30 ES009089, RD832141, R827027, RD834509)
  • New York Community Trust
  • Educational Foundation of America
  • Blanchette Hooker Rockefeller Fund
  • Centers for Disease Control and Prevention (ES009089)
  • National Institute of Environmental Health Sciences (P01ES009600, R00ES017051, R01ES008977, P30ES009089)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
bisphenol A, prenatal exposure, endocrine disruptors, child behavior, sex differences, developmental neurotoxicity, aggression, emotional reactivity, urinary BPA, inner-city children, African American women, Dominican women
MeSH terms
Bisphenol A Compounds, Benzhydryl Compounds, Child Behavior, Child, Preschool, Female, Hispanic or Latino, Humans, Male, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Urban Population, Cohort Studies

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