Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice
Abstract
Bisphenol A (BPA), an environmental endocrine‐disrupting chemical, has been extensively evaluated for reproductive toxicity and carcinogenicity. However, little is known about the behavioral and neurochemical effects of BPA exposure. This study examined whether chronic daily exposure to an environmental endocrine‐disrupting chemical, bisphenol A [(BPA); 100 μg/kg/day or 500 μg/kg/day, p.o.], from prenatal Day 7 to postnatal Day 36 would lead to changes in anxiety and memory in mice. First, we observed the behavioral alterations of BPA‐treated mice using two anxiety‐related models, the open field test and elevated plus maze (EPM) test. In the open field test, BPA treatment (100 μg/kg/day) increased movement in the central zone. BPA treatment (500 μg/kg/day) also increased the time spent in the open arms in the EPM test. Second, we measured cognitive ability in the Y‐maze test and novel object test. BPA‐treated mice showed decreased alternation behavior in the Y‐maze at both of doses, indicating working memory impairment. BPA‐treated mice (100 μg/kg/day) also showed decreased novel object recognition as expressed by central locomotion and frequency in the central zone, showing recognition memory impairment. Finally, to measure changes in the dopaminergic and NMDAergic systems in the brain, we performed autoradiographic receptor binding assays for dopamine D 1 and D 2 receptors, the NMDA receptor, and the dopamine transporter. BPA treatment increased D 2 receptor binding in the caudate putamen (CPu) but decreased DAT binding. BPA treatment also decreased NMDA receptor binding in the frontal cortex and CA1, CA3, and DG of the hippocampus. Taken together, our results suggest that long‐term BPA exposure in mice can induce anxiolytic behaviors, cognitive deficits and changes in the dopaminergic and NMDAergic systems. Synapse 64:432–439, 2010. © 2010 Wiley‐Liss, Inc.
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Pre- and/or peri-natal exposure to BPA in rodents is associated with cognitive impairments and decreased exploration in a novel environment.
“Pre- and/or peri-natal exposure to BPA in rodents is associated with cognitive impairments and decreased exploration in a novel environment [12], [13], [14].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [12]
BPA exposure is associated with cognitive and social impairments in rodents.
“and it is associated with cognitive and social impairments in rodents [ 48 , 133–135 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [135]
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- Authors
- Tian, Y., Baek, J., Lee, S., & Jang, C.
- Affiliations
- Ministry of Food and Drug Safety (KR)
- Sungkyunkwan University (KR)
- Corresponding author
- Jang, Choon‐Gon
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 2010-02-18
- Volume
- 64
- Issue
- 6
- Pages
- 432-439
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W1986018940
- Cited by
- 197
- References
- 50
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 6 · 2023: 10 · 2022: 15 · 2021: 17 · 2020: 12 · 2019: 12 · 2018: 16 · 2017: 11 · 2016: 13 · 2015: 16 · 2014: 12 · 2013: 11 · 2012: 11
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- bisphenol A, endocrine disruptors, prenatal exposure, postnatal exposure, anxiety-like behavior, cognitive impairment, working memory, recognition memory, dopamine D2 receptor, dopamine transporter, NMDA receptor, caudate-putamen, hippocampus, neurobehavioral effects
- MeSH terms
- Bisphenol A Compounds, Animals, Animals, Newborn, Behavior, Animal, Mental Disorders, Benzhydryl Compounds, Brain, Cognition Disorders, Disease Models, Animal, Estrogens, Non-Steroidal, Female, Frontal Lobe, Hippocampus, Memory Disorders, Mice, Inbred ICR, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Anti-Anxiety Agents, Receptors, N-Methyl-D-Aspartate, Receptors, Dopamine D1, Receptors, Dopamine D2, Maze Learning, Dopamine Plasma Membrane Transport Proteins, Mice
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