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In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing
Open accessAbstract
Significance: Monovalent ions, such as Na + , play important roles in biology, yet few sensors that image intracellular Na + have been reported. Although deoxyribozymes (DNAzymes) have been shown to be a promising platform for detection of metal ions, most reported DNAzymes require multivalent metal ions for catalytic activity. Existing monovalent ion-responsive DNAzymes have poor selectivity for Na + , low catalytic rate, and require high ion concentrations for function. Here, we report in vitro selection of the first (to our knowledge) highly selective, sensitive, and efficient Na + -specific, RNA-cleaving DNAzyme and its conversion into a catalytic beacon sensor for imaging Na + in living cells, using an efficient cationic polypeptide delivery method, together with a photocaging strategy, to allow controllable activation of the DNAzyme probe inside cells.
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Cited by
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Self-citationLake, R. J., Yang, Z., Zhang, J., & Lu, Y. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00419 · Cited by 281
Self-citationWu, Y., Torabi, S.-F., Lake, R. J., Hong, S., Yu, Z., Wu, P., Yang, Z., Nelson, K., Guo, W., Pawel, G. T., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7622 · Cited by 91
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Metadata
- Authors
- Torabi, S.-F., Wu, P., McGhee, C. E., Chen, L., Hwang, K., Zheng, N., Cheng, J., & Lu, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-04-27
- Volume
- 112
- Issue
- 19
- Pages
- 5903-5908
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979073863
- Cited by
- 347
- References
- 0
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Torabi, S.-F., Wu, P., McGhee, C. E., Chen, L., Hwang, K., Zheng, N., Cheng, J., & Lu, Y. (2015). In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1420361112
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