The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
Abstract
Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron deficiency and iron overload are associated with cardiomyopathy and heart failure via complex mechanisms. Although ferritin plays a central role in iron metabolism by storing excess cellular iron, the molecular function of ferritin in cardiomyocytes remains unknown. Objective: To characterize the functional role of Fth (ferritin H) in mediating cardiac iron homeostasis and heart disease. Methods and Results: Mice expressing a conditional Fth knockout allele were crossed with 2 distinct Cre recombinase-expressing mouse lines, resulting in offspring that lack Fth expression specifically in myocytes (MCK-Cre) or cardiomyocytes (Myh6-Cre). Mice lacking Fth in cardiomyocytes had decreased cardiac iron levels and increased oxidative stress, resulting in mild cardiac injury upon aging. However, feeding these mice a high-iron diet caused severe cardiac injury and hypertrophic cardiomyopathy, with molecular features typical of ferroptosis, including reduced glutathione (GSH) levels and increased lipid peroxidation. Ferrostatin-1, a specific inhibitor of ferroptosis, rescued this phenotype, supporting the notion that ferroptosis plays a pathophysiological role in the heart. Finally, we found that Fth-deficient cardiomyocytes have reduced expression of the ferroptosis regulator Slc7a11, and overexpressing Slc7a11 selectively in cardiomyocytes increased GSH levels and prevented cardiac ferroptosis. Conclusions: Our findings provide compelling evidence that ferritin plays a major role in protecting against cardiac ferroptosis and subsequent heart failure, thereby providing a possible new therapeutic target for patients at risk of developing cardiomyopathy.
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Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Self-citationHeart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Ferroptosis: process and function
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Self-citationFerroptosis as a p53-mediated activity during tumour suppression
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Autophagy promotes ferroptosis by degradation of ferritin
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Ferroptosis as a target for protection against cardiomyopathy
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Self-citationTwo to tango: Regulation of Mammalian iron metabolism
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Fang, X., Ardehali, H., Min, J., & Wang, F. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00735-4 · Cited by 1,081
Self-citationMechanisms controlling cellular and systemic iron homeostasis
Galy, B., Conrad, M., & Muckenthaler, M. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00648-1 · Cited by 785
Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Self-citationFerroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
Self-citationThe multifaceted role of ferroptosis in liver disease
Chen, J., Li, X., Ge, C., Min, J., & Wang, F. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-00941-0 · Cited by 665
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Metadata
- Authors
- Fang, X., Cai, Z., Wang, H., Han, D., Cheng, Q., Zhang, P., Gao, F., Yu, Y., Song, Z., Wu, Q., An, P., Huang, S., Pan, J., Chen, H.-Z., Chen, J., Linkermann, A., Min, J., & Wang, F.
- Venue
- Circulation Research
- Published
- 2020-07-31
- Volume
- 127
- Issue
- 4
- Pages
- 486-501
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W3020890805
- Cited by
- 770
- References
- 63
- FWCI
- 45.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fang, X., Cai, Z., Wang, H., Han, D., Cheng, Q., Zhang, P., Gao, F., Yu, Y., Song, Z., Wu, Q., An, P., Huang, S., Pan, J., Chen, H.-Z., Chen, J., Linkermann, A., Min, J., & Wang, F. (2020). Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis. Circulation Research. https://doi.org/10.1161/circresaha.120.316509
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