The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
De novo production of the plant-derived alkaloid strictosidine in yeast
Open accessAbstract
Significance: Plants make a wide variety of complex molecules with potent biological activities including several anticancer therapeutics. Unfortunately, plants often produce these molecules in low amounts, making them expensive to obtain. Engineering simpler organisms, such as yeast, to produce these plant-derived compounds provides one solution to production challenges. One group of plant-derived molecules, the monoterpene indole alkaloids, is synthesized from a common intermediate, strictosidine. Here, we report how we developed a yeast strain that produces strictosidine. This required introducing 21 new genes and three gene deletions into the yeast genome. This yeast strain provides an important resource for the production of expensive, complex molecules that plants normally produce in small amounts.
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Cites
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
High-level semi-synthetic production of the potent antimalarial artemisinin
Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060
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Cravens, A., Payne, J., & Smolke, C. D. (2019) · Nature Communications · doi:10.1038/s41467-019-09848-w · Cited by 438
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Urlacher, V. B., & Girhard, M. (2019) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.01.001 · Cited by 355
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Liu, Q., Yu, T., Li, X., Chen, Y., Campbell, K., Nielsen, J., & Chen, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-12961-5 · Cited by 328
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Liang, D.-M., Liu, J.-H., Wu, H., Wang, B.-B., Zhu, H.-J., & Qiao, J.-J. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00600g · Cited by 269
Hussain, M. H., Mohsin, M. Z., Zaman, W. Q., Yu, J., Zhao, X., Wei, Y., Zhuang, Y., Mohsin, A., & Guo, M. (2022) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.12.012 · Cited by 31
Metadata
- Authors
- Brown, S., Clastre, M., Courdavault, V., & O’Connor, S. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-02-09
- Volume
- 112
- Issue
- 11
- Pages
- 3205-3210
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011945340
- Cited by
- 455
- References
- 2
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Brown, S., Clastre, M., Courdavault, V., & O’Connor, S. E. (2015). De novo production of the plant-derived alkaloid strictosidine in yeast. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1423555112
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