The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota
Open accessAbstract
Significance: Ninety-five percent of adult-acquired infections lead to spontaneous clearance, whereas >90% of exposed neonates and ∼30% of children aged 1–5 y fail to resolve hepatitis B virus (HBV) and develop chronic infection. A strong, diverse, adaptive immune response is considered essential for HBV clearance, but the mechanisms to generate a favorable response remain elusive. Here, we show that, while 12-wk-old C3H/HeN mice cleared HBV within 6 wk postinjection (wpi), their 6-wk-old counterparts remained HBV-positive at 26 wpi. Sterilization of gut microbiota from 6 to 12 wk of age using antibiotics prevented mice from rapidly clearing HBV. This model is valuable to the study of liver tolerance and enables the investigation of the mechanisms involved in effective control of HBV.
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“A recent study demonstrated that the gut microbiota controls immune responses and tolerance to HBV in adult mice, with 6 weeks of antibiotic treatment preventing the clearance of HBV68.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [68]
Citations
Cites
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Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
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Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952
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Ganem, D., & Prince, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031087 · Cited by 2,361
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219
Hepatitis B: The virus and disease #
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“Liver sinusoid endothelial cells (LSECs) respond to Gram-negative bacteria-derived lipopolysaccharides (LPSs) through Toll-like receptor (TLR) 4 by the secretion of interleukin-10 (IL-10), which induces T-cell tolerance (17, 18).”
BackgroundIs a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
Milich, D. R., Jones, J. E., Hughes, J. L., Price, J. A., Raney, A. K., & McLachlan, A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6599 · Cited by 580
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Hepatitis B Virus-Related Liver Disease and Gut Microbiota: An Updated Review
Lv, D., Han, N., Liu, H., & Tang, H. (2025) · Microorganisms · doi:10.3390/microorganisms13112445
Long, J., Saw, M., Zhang, P., Wang, L., Li, L., Ren, H., Liu, C., Ma, Z., Zhang, J., & Wang, B. (2024) · Figshare · doi:10.6084/m9.figshare.27078803
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Long, J., Saw, M., Zhang, P., Wang, L., Li, L., Ren, H., Liu, C., Ma, Z., Zhang, J., & Wang, B. (2024) · Figshare · doi:10.6084/m9.figshare.27078791
Long, J., Saw, M., Zhang, P., Wang, L., Li, L., Ren, H., Liu, C., Ma, Z., Zhang, J., & Wang, B. (2024) · Figshare · doi:10.6084/m9.figshare.27078800
Long, J., Saw, M., Zhang, P., Wang, L., Li, L., Ren, H., Liu, C., Ma, Z., Zhang, J., & Wang, B. (2024) · Figshare · doi:10.6084/m9.figshare.27078782
Long, J., Saw, M., Zhang, P., Wang, L., Li, L., Ren, H., Liu, C., Ma, Z., Zhang, J., & Wang, B. (2024) · Figshare · doi:10.6084/m9.figshare.27078785
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Pellegrini, F., Burgio, M., Cicirelli, V., Diakoudi, G., Elia, G., Salvaggiulo, A., Filipponio, N., Profio, F. D., Sarchese, V., Cavasin, J. P., et al. (2026) · Veterinary Microbiology · doi:10.1016/j.vetmic.2026.110956
Gut Microbiota Alterations Associated with Viral Activity in Chronic Hepatitis B
Nasta, P., Gregorio, M. D., Zaia, M., & Carosi, G. (2026) · Archives of Case Reports · doi:10.29328/journal.acr.1001185
Alteration of alternative splicing in the pathogenesis of liver disease
Wang, H. (2017) · theses.fr (ABES) · doi:10.70675/bbd0da03z44bcz4adczaedazc17212ba6ebe
Self-citationHBV and the Microbiome—PubMed Database Literature Review
Prince, A. M., Zeltiņa, I., Reinis, A., Valciņa, O., & Krūmiņa, A. (2026) · Infectious Disease Reports · doi:10.3390/idr18030038
Gao, S., Zhuang, J., Cheng, H., Hu, K., 庄立伟, & Pan, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1949414
Xiang, H., He, T., Dou, Y., Chen, Q., Wu, P., Luo, Z., Xiang, H., & Zhang, J. (2026) · Pathogens · doi:10.3390/pathogens15111128
Metadata
- Authors
- Chou, H.-H., Chien, W.-H., Wu, L.-L., Cheng, C.-H., Chung, C.-H., Horng, J.-H., Ni, Y.-H., Tseng, H.-T., Wu, D., Lu, X., Wang, H.-Y., Chen, P.-J., & Chen, D.-S.
- Affiliations
- National Taiwan University (TW)
- Chinese Academy of Sciences (CN)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-02-02
- Volume
- 112
- Issue
- 7
- Pages
- 2175-2180
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4343154
- OpenAlex
- W2143865587
- Cited by
- 211
- References
- 34
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 19 · 2023: 18 · 2022: 18 · 2021: 24 · 2020: 31 · 2019: 22 · 2018: 14 · 2017: 21 · 2016: 10 · 2015: 11
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hepatitis B virus, viral clearance, age-related immunity, gut microbiota, TLR4, antibiotic-induced microbiota depletion, liver immunity, immune tolerance, C3H/HeN mice, C3H/HeJ mice
- MeSH terms
- Animals, Hepatitis B, Humans, Intestines, Mice, Inbred BALB C, Mice, Inbred NOD, Mice, Microbiota
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