The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota
Open accessAbstract
Significance: Ninety-five percent of adult-acquired infections lead to spontaneous clearance, whereas >90% of exposed neonates and ∼30% of children aged 1–5 y fail to resolve hepatitis B virus (HBV) and develop chronic infection. A strong, diverse, adaptive immune response is considered essential for HBV clearance, but the mechanisms to generate a favorable response remain elusive. Here, we show that, while 12-wk-old C3H/HeN mice cleared HBV within 6 wk postinjection (wpi), their 6-wk-old counterparts remained HBV-positive at 26 wpi. Sterilization of gut microbiota from 6 to 12 wk of age using antibiotics prevented mice from rapidly clearing HBV. This model is valuable to the study of liver tolerance and enables the investigation of the mechanisms involved in effective control of HBV.
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“A recent study demonstrated that the gut microbiota controls immune responses and tolerance to HBV in adult mice, with 6 weeks of antibiotic treatment preventing the clearance of HBV68.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [68]
Citations
Cites
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952
Hepatitis B Virus Infection — Natural History and Clinical Consequences
Ganem, D., & Prince, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031087 · Cited by 2,361
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219
Hepatitis B: The virus and disease #
Liang, J. T. (2009) · Hepatology · doi:10.1002/hep.22881 · Cited by 1,066
Limmer, A., Ohl, J., Kurts, C., Ljunggren, H.-G., Reiss, Y., Groettrup, M., Momburg, F., Arnold, B., & Knolle, P. A. (2000) · Nature Medicine · doi:10.1038/82161 · Cited by 758 · cited 1×
“Liver sinusoid endothelial cells (LSECs) respond to Gram-negative bacteria-derived lipopolysaccharides (LPSs) through Toll-like receptor (TLR) 4 by the secretion of interleukin-10 (IL-10), which induces T-cell tolerance (17, 18).”
BackgroundIs a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
Milich, D. R., Jones, J. E., Hughes, J. L., Price, J. A., Raney, A. K., & McLachlan, A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6599 · Cited by 580
Kamatani, Y., Wattanapokayakit, S., Ochi, H., Kawaguchi, T., Takahashi, A., Hosono, N., Kubo, M., Tsunoda, T., Kamatani, N., Kumada, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.348 · Cited by 514
Ayres, J. S., & Schneider, D. S. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075030 · Cited by 475
Cited by
Sorted by citations
The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634
Milosevic, I., Vujovic, A., Barac, A., Djelic, M., Korac, M., Radovanovic Spurnic, A., Gmizic, I., Stevanovic, O., Djordjevic, V., Lekic, N., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020395 · Cited by 551
Gut microbiome, liver immunology, and liver diseases
Wang, R., Tang, R., Li, B., Ma, X., Schnabl, B., & Tilg, H. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00592-6 · Cited by 466
Gut–liver axis: barriers and functional circuits
Pabst, O., Hornef, M. W., Schaap, F. G., Cerovic, V., Clavel, T., & Bruns, T. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00771-6 · Cited by 488
Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes
Li, W., & Duffy, A. J. (2017) · Journal of Nutrition · doi:10.3945/jn.116.240754 · Cited by 433
Metadata
- Authors
- Chou, H.-H., Chien, W.-H., Wu, L.-L., Cheng, C.-H., Chung, C.-H., Horng, J.-H., Ni, Y.-H., Tseng, H.-T., Wu, D., Lu, X., Wang, H.-Y., Chen, P.-J., & Chen, D.-S.
- Affiliations
- National Taiwan University (TW)
- Chinese Academy of Sciences (CN)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-02-02
- Volume
- 112
- Issue
- 7
- Pages
- 2175-2180
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4343154
- OpenAlex
- W2143865587
- Cited by
- 211
- References
- 34
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 19 · 2023: 18 · 2022: 18 · 2021: 24 · 2020: 31 · 2019: 22 · 2018: 14 · 2017: 21 · 2016: 10 · 2015: 11
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hepatitis B virus, viral clearance, age-related immunity, gut microbiota, TLR4, antibiotic-induced microbiota depletion, liver immunity, immune tolerance, C3H/HeN mice, C3H/HeJ mice
- MeSH terms
- Animals, Hepatitis B, Humans, Intestines, Mice, Inbred BALB C, Mice, Inbred NOD, Mice, Microbiota
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