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Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota
Open accessAbstract
Significance: Ninety-five percent of adult-acquired infections lead to spontaneous clearance, whereas >90% of exposed neonates and ∼30% of children aged 1–5 y fail to resolve hepatitis B virus (HBV) and develop chronic infection. A strong, diverse, adaptive immune response is considered essential for HBV clearance, but the mechanisms to generate a favorable response remain elusive. Here, we show that, while 12-wk-old C3H/HeN mice cleared HBV within 6 wk postinjection (wpi), their 6-wk-old counterparts remained HBV-positive at 26 wpi. Sterilization of gut microbiota from 6 to 12 wk of age using antibiotics prevented mice from rapidly clearing HBV. This model is valuable to the study of liver tolerance and enables the investigation of the mechanisms involved in effective control of HBV.
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“A recent study demonstrated that the gut microbiota controls immune responses and tolerance to HBV in adult mice, with 6 weeks of antibiotic treatment preventing the clearance of HBV68.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [68]
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Metadata
- Authors
- Chou, H.-H., Chien, W.-H., Wu, L.-L., Cheng, C.-H., Chung, C.-H., Horng, J.-H., Ni, Y.-H., Tseng, H.-T., Wu, D., Lu, X., Wang, H.-Y., Chen, P.-J., & Chen, D.-S.
- Affiliations
- National Taiwan University (TW)
- Chinese Academy of Sciences (CN)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-02-02
- Volume
- 112
- Issue
- 7
- Pages
- 2175-2180
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4343154
- OpenAlex
- W2143865587
- Cited by
- 211
- References
- 34
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 19 · 2023: 18 · 2022: 18 · 2021: 24 · 2020: 31 · 2019: 22 · 2018: 14 · 2017: 21 · 2016: 10 · 2015: 11
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hepatitis B virus, viral clearance, age-related immunity, gut microbiota, TLR4, antibiotic-induced microbiota depletion, liver immunity, immune tolerance, C3H/HeN mice, C3H/HeJ mice
- MeSH terms
- Animals, Hepatitis B, Humans, Intestines, Mice, Inbred BALB C, Mice, Inbred NOD, Mice, Microbiota
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