The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus
Open accessAbstract
Significance: Staphylococcus aureus is a human pathogen causing life-threatening infections. The high incidence of methicillin-resistant S. aureus isolates resistant to all antibiotics makes the development of anti -S. aureus vaccines an urgent medical need. However, the unique ability of S. aureus to produce virulent factors, which counteract virtually all pathways of innate and adaptive immunity, has hampered all vaccine discovery efforts. Starting from the assumption that to be effective a vaccine should induce highly functional antibodies and potentiate the killing capacity of phagocytic cells, we selected a cocktail of five conserved antigens involved in different mechanisms of pathogenesis, and we formulated them with a potent adjuvant. This vaccine provides an unprecedented protective efficacy against S. aureus infection in animal models.
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Kennedy, A. D., Wardenburg, J. B., Gardner, D. J., Long, D., Whitney, A. R., Braughton, K. R., Schneewind, O., & DeLeo, F. R. (2010) · The Journal of Infectious Diseases · doi:10.1086/656043 · Cited by 335
Self-citationKuklin, N. A., Clark, D. J., Secore, S., Cook, J., Cope, L. D., McNeely, T., Noble, L., Brown, M. J., Zorman, J. K., Wang, X. M., et al. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2215-2223.2006 · Cited by 264
Kim, H. K., DeDent, A., Cheng, A. G., McAdow, M., Bagnoli, F., Missiakas, D. M., & Schneewind, O. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.097 · Cited by 158
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Cited by
Holland, T. L., Baddour, L. M., Bayer, A. S., Hoen, B., Miro, J. M., & Fowler, V. G. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.59 · Cited by 406
Chiang, C.-Y., Uzoma, I., Moore, R. T., Gilbert, M., Duplantier, A. J., & Panchal, R. G. (2018) · mBio · doi:10.1128/mbio.01932-17 · Cited by 95
Metadata
- Authors
- Bagnoli, F., Fontana, M. R., Soldaini, E., Mishra, R. P. N., Fiaschi, L., Cartocci, E., Nardi-Dei, V., Ruggiero, P., Nosari, S., De Falco, M. G., Lofano, G., Marchi, S., Galletti, B., Mariotti, P., Bacconi, M., Torre, A., Maccari, S., Scarselli, M., Rinaudo, C. D., Inoshima, N., Savino, S., Mori, E., Rossi-Paccani, S., Baudner, B., Pallaoro, M., Swennen, E., Petracca, R., Brettoni, C., Liberatori, S., Norais, N., Monaci, E., Bubeck Wardenburg, J., Schneewind, O., O’Hagan, D. T., Valiante, N. M., Bensi, G., Bertholet, S., De Gregorio, E., Rappuoli, R., & Grandi, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-03-09
- Volume
- 112
- Issue
- 12
- Pages
- 3680-3685
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965495205
- Cited by
- 177
- References
- 3
- FWCI
- 21.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Bagnoli, F., Fontana, M. R., Soldaini, E., Mishra, R. P. N., Fiaschi, L., Cartocci, E., Nardi-Dei, V., Ruggiero, P., Nosari, S., De Falco, M. G., Lofano, G., Marchi, S., Galletti, B., Mariotti, P., Bacconi, M., Torre, A., Maccari, S., Scarselli, M., Rinaudo, C. D., . . . Grandi, G. (2015). Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1424924112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
