Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges
Open accessAbstract
Increasing incidences of multidrug resistance in pathogenic bacteria threaten our ability to treat and manage bacterial infection. The development and FDA approval of novel antibiotics have slowed over the past decade; therefore, the adoption and improvement of alternative therapeutic strategies are critical for addressing the threat posed by multidrug-resistant bacteria. Host-directed therapies utilize small-molecule drugs and proteins to alter the host response to pathogen infection. Here, we highlight strategies for modulating the host inflammatory response to enhance bacterial clearance, small-molecule potentiation of innate immunity, and targeting of host factors that are exploited by pathogen virulence factors. Application of state-of-the-art “omic” technologies, including proteomics, transcriptomics, and image-omics (image-based high-throughput phenotypic screening), combined with powerful bioinformatics tools will enable the modeling of key signaling pathways in the host-pathogen interplay and aid in the identification of host proteins for therapeutic targeting and the discovery of host-directed small molecules that will regulate bacterial infection. We conclude with an outlook on research needed to overcome the challenges associated with transitioning host-directed therapies into a clinical setting.
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Drug combinations have been utilized efficiently to treat various bacterial and viral infections and cancer.
“Historically, drug combinations have been utilized efficiently to treat various bacterial and viral infections and to fight cancer [18–21].”
From Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of<i>Candida auris</i>and displays potent synergistic interactions with azole drugs (2020) · cites this paper as [19]
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Self-citationChiang, C.-Y., Uzoma, I., Lane, D. J., et al. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00683 · Cited by 14 · see citing works
Self-citationAlbers, H. M. H. G., Kuijl, C. P., Bakker, J., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400421a · Cited by 12 · see citing works
Kota, K. P., Eaton, B., Lane, D. J., Ulrich, M. P., Ulrich, R. L., Peyser, B. D., Robinson, C. G., Jaissle, J. G., Pegoraro, G., Bavari, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055167 · Cited by 11 · see citing works
Self-citationCasanova, A., Low, S. H., Emmenlauer, M., et al. (2016) · Journal of Visualized Experiments · doi:10.3791/54263 · Cited by 7 · see citing works
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Eldesouky, H. E., Salama, E. A., Lanman, N. A., Hazbun, T. R., & Seleem, M. N. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-20 · Cited by 56 · see citing works
Eldesouky, H. E., Lanman, N. A., Hazbun, T. R., & Seleem, M. N. (2020) · Virulence · doi:10.1080/21505594.2020.1838741 · Cited by 37 · see citing works
- Authors
- Chiang, C.-Y., Uzoma, I., Moore, R. T., Gilbert, M., Duplantier, A. J., & Panchal, R. G.
- Affiliations
- United States Army Medical Research Institute of Infectious Diseases (US)
- Corresponding author
- Panchal, Rekha G.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2018-03-07
- Volume
- 9
- Issue
- 1
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC5790911
- OpenAlex
- W2794263799
- Cited by
- 95
- References
- 97
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 19 · 2019: 9 · 2018: 5
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- DOD | Defense Threat Reduction Agency (13267645)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- host-directed therapy, antibiotic resistance, multidrug-resistant bacteria, host inflammatory response, host-pathogen interaction, bacterial virulence factors, bacterial clearance
- MeSH terms
- Bacterial Infections, Humans, Immunologic Factors, Computational Biology, Drug Resistance, Multiple, Bacterial, Host-Pathogen Interactions, Drug Discovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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