The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
A large pool of releasable vesicles in a cortical glutamatergic synapse
Open accessAbstract
To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool." Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Capacitance measurements from hippocampal mossy fiber terminals suggest that long depolarizing pulses release approximately 500–1,400 vesicles, corresponding to 17 to 48 vesicles per AZ [33,86].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [86]
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
The NEURON Simulation Environment
Hines, M. L., & Carnevale, N. T. (1997) · Neural Computation · doi:10.1162/neco.1997.9.6.1179 · Cited by 2,630
Sakmann, B. J., & Neher, E. (1995) · Springer eBooks · doi:10.1007/978-1-4419-1229-9 · Cited by 2,543
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
The release of neural transmitter substances
Katz, B. (1969) · Medical Entomology and Zoology · Cited by 1,126
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
Neher, E., & Marty, A. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.21.6712 · Cited by 1,004
Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular Junction
Betz, W. J., & Bewick, G. S. (1992) · Science · doi:10.1126/science.1553547 · Cited by 763
Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons
Zalutsky, R. A., & Nicoll, R. A. (1990) · Science · doi:10.1126/science.2114039 · Cited by 759
GABAergic Cells Are the Major Postsynaptic Targets of Mossy Fibers in the Rat Hippocampus
Acsády, L., Kamondi, A., Sı́k, A., Freund, T., & Buzsáki, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03386.1998 · Cited by 741
Cited by
Sorted by citations
Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release
Neher, E., & Sakaba, T. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.019 · Cited by 966
Granseth, B., Odermatt, B., Royle, S. J., & Lagnado, L. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.029 · Cited by 686
Ultrafast endocytosis at mouse hippocampal synapses
Watanabe, S., Rost, B. R., Camacho-Pérez, M., Davis, M. W., Söhl-Kielczynski, B., Rosenmund, C., & Jorgensen, E. M. (2013) · Nature · doi:10.1038/nature12809 · Cited by 607
Isolation of rare cells from cell mixtures by dielectrophoresis
Gascoyne, P. R. C., Noshari, J., Anderson, T. J., & Becker, F. F. (2009) · Electrophoresis · doi:10.1002/elps.200800373 · Cited by 436
Combined Analog and Action Potential Coding in Hippocampal Mossy Fibers
Alle, H., & Geiger, J. R. P. (2006) · Science · doi:10.1126/science.1119055 · Cited by 348
Metadata
- Authors
- Hallermann, S., Pawlu, C., Jonas, P., & Heckmann, M.
- Affiliations
- University of Freiburg (DE)
- Physiologisches Institut, Universität Freiburg, D-79104 Freiburg, Germany
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-06-18
- Volume
- 100
- Issue
- 15
- Pages
- 8975-8980
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC166423
- OpenAlex
- W2133521893
- Cited by
- 181
- References
- 60
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 7 · 2019: 13 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 4
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- exocytosis, glutamatergic synapses, hippocampal mossy fibers, synaptic vesicles, capacitance measurement, presynaptic calcium influx, vesicle recycling, activity-dependent plasticity, equivalent circuit model
- MeSH terms
- Animals, Electrophysiology, Endocytosis, Exocytosis, Models, Neurological, Synaptic Transmission, Rats, Wistar, Mossy Fibers, Hippocampal, Secretory Vesicles, Electric Capacitance, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
