Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons
Abstract
In invertebrate nervous systems, some long-lasting increases in synaptic efficacy result from changes in the presynaptic cell. In the vertebrate nervous system, the best understood long-lasting change in synaptic strength is long-term potentiation (LTP) in the CA1 region of the hippocampus. Here the process is initiated postsynaptically, but the site of the persistent change is unresolved. Single CA3 hippocampal pyramidal cells receive excitatory inputs from associational-commissural fibers and from the mossy fibers of dentate granule cells and both pathways exhibit LTP. Although the induction of associational-commissural LTP requires in the postsynaptic cell N-methyl-D-aspartate (NMDA) receptor activation, membrane depolarization, and a rise in calcium, mossy fiber LTP does not. Paired-pulse facilitation, which is an index of increased transmitter release, is unaltered during associational-commissural LTP but is reduced during mossy fiber LTP. Thus, both the induction and the persistent change may be presynaptic in mossy fiber LTP but not in associational-commissural LTP.
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Application of NMDAR antagonists such as AP5 completely blocks the induction of LTP in most hippocampal synapses.
“For instance, application of NMDAR antagonists (such as 2-amino-5-phosphonopropionic acid [AP5]) completely blocks the induction of LTP in most hippocampal synapses (Collingridge et al., 1983; Zalutsky and Nicoll, 1990; Hanse and Gustafsson, 1992).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Zalutsky and Nicoll, 1990
Mossy fiber LTP may require an increase in presynaptic Ca2+.
“In contrast to NMDA receptor-dependent LTP, which depends on increased postsynaptic Ca 2ϩ , mossy fiber LTP may require an increase in presynaptic Ca 2ϩ (Zalutsky and Nicoll, 1990) (but see Jaffe and Johnston, 1990;Urban and Barrionuevo, 1996).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Zalutsky and Nicoll, 1990
Mossy fiber LTP is NMDA-independent.
“For example, perforant path and the Schaffer collateral pathway LTP are both dependent on the activation of NMDA receptors (Bliss and Collingridge, 1993), whereas mossy fiber/CA3 LTP is not (Harris and Cotman, 1986;Z alutsky and Nicoll, 1990).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Zalutsky and Nicoll, 1990
Mossy fiber LTP is dependent on increases in intracellular Ca2+.
“Although mossy fiber LTP is dependent on increases in intracellular Ca 2ϩ (Zalutsky and Nicoll, 1990;Johnston et al., 1992;Y. Y. Huang et al., 1994), the molecular mechanism for LTP at the mossy fiber3 CA3 pyramidal cell synapse is not known.”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Zalutsky and Nicoll, 1990
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- Authors
- Zalutsky, R. A., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Nicoll, Roger A.
- Venue
- Science
- Published
- 1990-06-29
- Volume
- 248
- Issue
- 4963
- Pages
- 1619-1624
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970053578
- Cited by
- 759
- References
- 1
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 5 · 2017: 17 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 14
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns024205-07)
- National Institute of Mental Health (MH-38256, MH0437)
- National Institute of Neurological Disorders and Stroke (NS 24205)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, hippocampus, CA3 pyramidal cells, mossy fibers, presynaptic plasticity, NMDA receptor, paired-pulse facilitation, synaptic transmission, dentate gyrus granule cells, synaptic efficacy
- MeSH terms
- Animals, Egtazic Acid, Electric Stimulation, Evoked Potentials, Fluorides, Guinea Pigs, Hippocampus, Membrane Potentials, Microelectrodes, Neurons, Synapses, In Vitro Techniques
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