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Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin
Open accessAbstract
In mammals and plants, formation of heterochromatin is associated with hypermethylation of DNA at CpG sites and histone H3 methylation at lysine 9. Previous studies have revealed that maintenance of DNA methylation in Neurospora and Arabidopsis requires histone H3 methylation. A feedback loop from DNA methylation to histone methylation, however, is less understood. Its recent examination in Arabidopsis with a partial loss of function in DNA methyltransferase 1 (responsible for maintenance of CpG methylation) yielded conflicting results. Here we report that complete removal of CpG methylation in an Arabidopsis mutant null for DNA maintenance methyltransferase results in a clear loss of histone H3 methylation at lysine 9 in heterochromatin and also at heterochromatic loci that remain transcriptionally silent. Surprisingly, these dramatic alterations are not reflected in heterochromatin relaxation.
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Cites
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
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Epigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232
DNA methylation pathways and their crosstalk with histone methylation
Du, J., Johnson, L. M., Jacobsen, S. E., & Patel, D. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4043 · Cited by 1,000
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
Stroud, H., Greenberg, M. V. C., Feng, S., Bernatavichute, Y. V., & Jacobsen, S. E. (2013) · Cell · doi:10.1016/j.cell.2012.10.054 · Cited by 873
Chuang, J. C., & Jones, P. A. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180457684 · Cited by 668
Chromatin immunoprecipitation: optimization, quantitative analysis and data normalization
Haring, M., Offermann, S., Danker, T., Horst, I., Peterhansel, C., & Stam, M. (2007) · Plant Methods · doi:10.1186/1746-4811-3-11 · Cited by 508
Metadata
- Authors
- Tariq, M., Saze, H., Probst, A. V., Lichota, J., Habu, Y., & Paszkowski, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-07-09
- Volume
- 100
- Issue
- 15
- Pages
- 8823-8827
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019525237
- Cited by
- 310
- References
- 2
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Tariq, M., Saze, H., Probst, A. V., Lichota, J., Habu, Y., & Paszkowski, J. (2003). Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1432939100
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