Cited by 1,000Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

DNA methylation pathways and their crosstalk with histone methylation

Open access
Du, Jiamu, Johnson, Lianna M., Jacobsen, Steven E., Patel, Dinshaw J.·2015·Nature Reviews Molecular Cell Biology

Abstract

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.

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Authors
Du, J., Johnson, L. M., Jacobsen, S. E., & Patel, D. J.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Howard Hughes Medical Institute (US)
  • Memorial Sloan Kettering Cancer Center (US)
Corresponding author
  • Jacobsen, Steven E.
  • Patel, Dinshaw J.
Venue
Nature Reviews Molecular Cell Biology
Published
2015-08-21
Volume
16
Issue
9
Pages
519-532
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W1681030413
Cited by
1,000
References
171
Citations by year
2026: 47 · 2025: 92 · 2024: 67 · 2023: 117 · 2022: 108 · 2021: 121 · 2020: 108 · 2019: 93 · 2018: 86 · 2017: 89 · 2016: 65 · 2015: 4
FWCI
7.91
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • Starr Foundation
  • Chinese Academy of Sciences
  • National Cancer Institute (P30CA008748)
  • National Institute of General Medical Sciences (GM60398, R37GM060398, R01GM060398)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords
DNA methylation, histone methylation, H3K9 methylation, epigenetic crosstalk, gene silencing, epigenetic inheritance
MeSH terms
DNA (Cytosine-5-)-Methyltransferase 1, Animals, DNA (Cytosine-5-)-Methyltransferases, Histones, Humans, Models, Molecular, Protein Binding, Protein Conformation, Protein Processing, Post-Translational, DNA Methylation, CCAAT-Enhancer-Binding Proteins, Epigenesis, Genetic, Ubiquitin-Protein Ligases

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