DNA methylation pathways and their crosstalk with histone methylation
Open accessAbstract
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.
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- Authors
- Du, J., Johnson, L. M., Jacobsen, S. E., & Patel, D. J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Howard Hughes Medical Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Jacobsen, Steven E.
- Patel, Dinshaw J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-08-21
- Volume
- 16
- Issue
- 9
- Pages
- 519-532
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC4672940
- OpenAlex
- W1681030413
- Cited by
- 1,000
- References
- 171
- Citations by year
- 2026: 47 · 2025: 92 · 2024: 67 · 2023: 117 · 2022: 108 · 2021: 121 · 2020: 108 · 2019: 93 · 2018: 86 · 2017: 89 · 2016: 65 · 2015: 4
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Starr Foundation
- Chinese Academy of Sciences
- National Cancer Institute (P30CA008748)
- National Institute of General Medical Sciences (GM60398, R37GM060398, R01GM060398)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- DNA methylation, histone methylation, H3K9 methylation, epigenetic crosstalk, gene silencing, epigenetic inheritance
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, Animals, DNA (Cytosine-5-)-Methyltransferases, Histones, Humans, Models, Molecular, Protein Binding, Protein Conformation, Protein Processing, Post-Translational, DNA Methylation, CCAAT-Enhancer-Binding Proteins, Epigenesis, Genetic, Ubiquitin-Protein Ligases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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