The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Genetics of diffuse large B-cell lymphoma
Open accessAbstract
Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy, remains a significant clinical challenge, as ∼30% of patients are not cured. Over the past decade, remarkable progress has been made in the understanding of the pathogenesis of this disease, spurred by the implementation of powerful genomic technologies that enabled the definition of its genetic and epigenetic landscape. These studies have uncovered a multitude of genomic alterations that contribute to the initiation and maintenance of the tumor clone by disrupting biological functions known to be critical for the normal biology of its cells of origin, germinal center B cells. The identified alterations involve epigenetic remodeling, block of differentiation, escape from immune surveillance, and the constitutive activation of several signal transduction pathways. This wealth of new information offers unique opportunities for the development of improved diagnostic and prognostic tools that could help guide the clinical management of DLBCL patients. Furthermore, a number of the mutated genes identified are potentially actionable targets that are currently being explored for the development of novel therapeutic strategies. This review summarizes current knowledge of the most common genetic alterations associated with DLBCL in relation to their functional impact on the malignant transformation process, and discusses their clinical implications for mechanism-based therapeutics.
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Cites
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Self-citationA Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo
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Cited by
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape
Wang, L.-H., Aberin, M. A. E., Wu, S., & Wang, S.-P. (2021) · Biochemical Society Transactions · doi:10.1042/bst20191164 · Cited by 53
RHO Family GTPases in the Biology of Lymphoma
Voena, C., & Chiarle, R. (2019) · Cells · doi:10.3390/cells8070646 · Cited by 35
Metadata
- Authors
- Pasqualucci, L., & Dalla-Favera, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-05-24
- Volume
- 131
- Issue
- 21
- Pages
- 2307-2319
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2800080453
- Cited by
- 282
- References
- 11
- FWCI
- 20.41
- Type
- journal article
- Language
- en
- Open access
- green
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