The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa
Open accessAbstract
Significance: In their natural environments, bacteria frequently transition from a free-swimming state to a surface-associated state, attached to a substratum. As they encounter a surface, they may initiate developmental programs to optimally colonize this new environment and induce pathways such as virulence. Here we demonstrate that the pathogen Pseudomonas aeruginosa uses fiber-like motorized appendages called type IV pili to sense initial contact with surfaces. This leads to a signaling cascade that results in the expression of hundreds of genes associated with pathogenicity and surface-specific twitching motility. Thus, bacteria use pili not only to attach and move, but also to sense mechanical features of their environment and regulate cellular processes of surface-associated lifestyles.
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Citations
Cites
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host Cells
Galán, J. E., & Collmer, A. (1999) · Science · doi:10.1126/science.284.5418.1322 · Cited by 1,319
The type III secretion injectisome
Cornelis, G. R. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1526 · Cited by 1,067
The type III secretion system of Pseudomonas aeruginosa: infection by injection
Hauser, A. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2199 · Cited by 968
Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action
Burrows, L. L. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150055 · Cited by 669
Direct observation of extension and retraction of type IV pili
Skerker, J. M., & Berg, H. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121171698 · Cited by 631
Signal processing in complex chemotaxis pathways
Porter, S. L., Wadhams, G. H., & Armitage, J. P. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2505 · Cited by 465
Biofilms, flagella, and mechanosensing of surfaces by bacteria
Belas, R. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.05.002 · Cited by 399
Wolfgang, M. C., Lee, V. T., Gilmore, M. E., & Lory, S. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00019-4 · Cited by 397
Single pilus motor forces exceed 100 pN
Maier, B., Potter, L., So, M., Seifert, H. S., & Sheetz, M. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242523299 · Cited by 396
Vfr controls quorum sensing in Pseudomonas aeruginosa
Albus, A. M., Pesci, E. C., Runyen-Janecky, L. J., West, S. E., & Iglewski, B. H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.12.3928-3935.1997 · Cited by 325
Cited by
Costa, C. M., Cardoso, V. F., Martins, P., Correia, D. M., Gonçalves, R., Costa, P., Correia, V., Ribeiro, C., Fernandes, M. M., Martins, P. M., et al. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00196 · Cited by 498
Bacterial motility: machinery and mechanisms
Wadhwa, N., & Berg, H. C. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00626-4 · Cited by 465
Mechanomicrobiology: how bacteria sense and respond to forces
Dufrêne, Y. F., & Persat, A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0314-2 · Cited by 299
Self-citationPseudomonas aeruginosa and microbial keratitis
Hilliam, Y., Kaye, S., & Winstanley, C. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001110 · Cited by 152
Not Just Going with the Flow: The Effects of Fluid Flow on Bacteria and Plankton
Wheeler, J. D., Secchi, E., Rusconi, R., & Stocker, R. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125119 · Cited by 139
Metadata
- Authors
- Persat, A., Inclan, Y. F., Engel, J. N., Stone, H. A., & Gitai, Z.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-03
- Volume
- 112
- Issue
- 24
- Pages
- 7563-7568
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1531320623
- Cited by
- 424
- References
- 30
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Persat, A., Inclan, Y. F., Engel, J. N., Stone, H. A., & Gitai, Z. (2015). Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1502025112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
