Pseudomonas aeruginosa and microbial keratitis

Hilliam, Yasmin; Kaye, Stephen; Winstanley, Craig

doi:10.1099/jmm.0.001110

Cited by 152Ocular Infections and TreatmentsBacterial biofilms and quorum sensingAntibiotic Resistance in Bacteria

Pseudomonas aeruginosa and microbial keratitis

Hilliam, Yasmin, Kaye, Stephen, Winstanley, Craig·2020·Journal of Medical Microbiology

DOI 10.1099/jmm.0.001110

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Abstract

Pseudomonas aeruginosa , a versatile Gram-negative pathogen that can cause a wide range of infections, is the most common causative agent in cases of bacterial keratitis associated with contact-lens use. Corneal infections with P. aeruginosa often have poor clinical outcomes and can result in long and costly treatments. During the infection process, the pathogen exploits its large genome, encoding complex regulatory networks and a wide range of virulence factors, including motility and the secretion of various proteases and toxins. Although antibiotic resistance levels in the UK are low, higher levels have been seen in some other countries. In the face of increasing antibiotic resistance, alternative therapeutic approaches such as antivirulence strategies and phage therapy are being developed. There is increasing evidence to suggest that keratitis infections are associated with a phylogenetic subgroup of P. aeruginosa isolates carrying the gene encoding the potent cytotoxin exotoxin U, one of two mutually exclusive exotoxins secreted via the type III secretion system. The mechanisms behind this association are unclear, but understanding the genetic differences that predispose P. aeruginosa to cause corneal infections may allow for the development of targeted and more effective future treatments to reduce the morbidity of P. aeruginosa keratitis. In order to minimize the risk of severe P. aeruginosa eye infections, a wide range of contact-lens disinfection solutions are available. Constant exposure to biocides at a range of concentrations, from sub-inhibitory to inhibitory, could contribute to the development of resistance to both antibiotics and disinfectants.

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BK is a rapidly progressive infectious corneal disorder that can cause corneal perforation, intraocular infection, permanent corneal opacification and vision loss.
“BK is a rapidly progressive infectious corneal disorder that can cause corneal perforation, intraocular infection, permanent corneal opacification and vision loss [130].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [130]

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Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment
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ROS-scavenging glyco-nanoplatform for synergistic antibacterial and wound-healing therapy of bacterial keratitis
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“BK is a rapidly progressive infectious corneal disorder that can cause corneal perforation, intraocular infection, permanent corneal opacification and vision loss [130].”

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ISOLATION AND PURIFICATION OF ANTICANCER PROTEIN EXOTXIN A FROM Pseudomonas aeruginosa
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Contact lens related microbial keratitis – avoidable blindness
Tallouzi, M., & Khodabukus, R. (2011) · International Journal of Ophthalmic Practice · doi:10.12968/ijop.2011.2.5.208

Authors: Hilliam, Y., Kaye, S., & Winstanley, C.
Affiliations: University of Liverpool (GB)
ORCID: Hilliam, Yasmin
Kaye, Stephen
Winstanley, Craig
Venue: Journal of Medical Microbiology
Publisher: Microbiology Society
Published: 2020-01-01
Volume: 69
Issue: 1
Pages: 3-13
ISSN: 0022-2615 (ISSN-L)
1473-5644
DOI: 10.1099/jmm.0.001110
OpenAlex: W2991230987
Cited by: 152
References: 105
Citations by year: 2026: 13 · 2025: 19 · 2024: 25 · 2023: 34 · 2022: 27 · 2021: 25 · 2020: 9
FWCI: 2.82
Type: journal article
Language: en
Open access: closed
Locations: Journal of Medical Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords: Pseudomonas aeruginosa, bacterial keratitis, contact lens-associated infection, virulence factors, type III secretion system, antibiotic resistance, disinfectant resistance, anti-virulence strategies, phage therapy, corneal infection
MeSH terms: Contact Lenses, Exotoxins, Genotype, Humans, Keratitis, Pseudomonas aeruginosa, Pseudomonas Infections, Global Health, Drug Resistance, Bacterial, Virulence Factors

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Pseudomonas aeruginosa and microbial keratitis

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