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Coordinate Regulation of Bacterial Virulence Genes by a Novel Adenylate Cyclase-Dependent Signaling Pathway
Open accessAbstract
Type III secretion systems (TTSSs) are utilized by numerous bacterial pathogens to inject effector proteins directly into host cells. Using a whole-genome microarray, we investigated the conditions and regulatory factors that control the expression of the Pseudomonas aeruginosa TTSS. The transcriptional response of known TTSS genes indicates a hierarchical pattern of expression in which a set of secretion apparatus and regulatory genes is constitutively expressed. Further analysis of genes coordinately regulated with those encoding the TTSS led to the identification of a signaling pathway that originates from a membrane-associated adenylate cyclase and controls TTSS gene expression. Transcriptome analysis of mutants lacking the ability to synthesize cAMP or the cAMP binding protein Vfr implicated this pathway in the global regulation of host-directed virulence determinants, including the TTSS.
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Citations
Cited by
Valentini, M., & Filloux, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.711507 · Cited by 668
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
Hogan, D. A., Vik, Å., & Kolter, R. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04349.x · Cited by 575
Déziel, E., Gopalan, S., Tampakaki, A. P., Lépine, F., Padfield, K. E., Saucier, M., Xiao, G., & Rahme, L. G. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04448.x · Cited by 417
Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA
Brencic, A., & Lory, S. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06670.x · Cited by 346
Self-citationGooderham, W. J., & Hancock, R. E. W. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00135.x · Cited by 346
Metadata
- Authors
- Wolfgang, M. C., Lee, V. T., Gilmore, M. E., & Lory, S.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 4
- Issue
- 2
- Pages
- 253-263
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2056134018
- Cited by
- 397
- References
- 0
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wolfgang, M. C., Lee, V. T., Gilmore, M. E., & Lory, S. (2003). Coordinate Regulation of Bacterial Virulence Genes by a Novel Adenylate Cyclase-Dependent Signaling Pathway. Developmental Cell. https://doi.org/10.1016/s1534-5807(03)00019-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
