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Behavioral idiosyncrasy reveals genetic control of phenotypic variability
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Abstract
Significance: If we could rear genetically identical individuals from a variety of genetic backgrounds and rear them in the same environment, how much phenotypic variation between individuals of the same genotype would we see? Would different genetic backgrounds differ in their degree of variability? What would account for these differences? We used Drosophila inbred lines to address these questions focusing on variability in locomotor handedness. We show that different genotypes vary dramatically in their propensity for variability, that phenotypic variability itself, as a trait, can be heritable, and that loci affecting variability can be mapped. The genetic control of variability has received little attention in quantitative genetics despite the important role variability plays in explaining phenotypic variation between individuals.
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“Our results also provide insight into mechanisms underlying individual differences in navigation behavior53,54.”
From Multimodal cue integration and learning in a neural representation of head direction (2025) · cites this paper as [53]
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“[26] Ayroles JF, Buchanan SM, O’Leary C, Skutt-Kakaria K, Grenier JK, Clark AG, et al.”
Background
Metadata
- Authors
- Ayroles, J. F., Buchanan, S. M., O’Leary, C., Skutt-Kakaria, K., Grenier, J. K., Clark, A. G., Hartl, D. L., & de Bivort, B. L.
- Affiliations
- Harvard University (US)
- Cornell University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-05-07
- Volume
- 112
- Issue
- 21
- Pages
- 6706-6711
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4450409
- OpenAlex
- W2112316313
- Cited by
- 218
- References
- 54
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 20 · 2023: 20 · 2022: 18 · 2021: 20 · 2020: 22 · 2019: 13 · 2018: 24 · 2017: 15 · 2016: 14 · 2015: 8
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University) (cc-by)
- Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (AI064950)
- Society of Fellows, Harvard University (N/A)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- phenotypic variability, central complex, brain gene expression, genotype-phenotype correlation, alternative alleles
- MeSH terms
- Animals, Behavior, Animal, Brain, Drosophila melanogaster, Female, Inbreeding, Locomotion, Male, Phenotype, Receptors, Cell Surface, Genetic Variation, Genes, Insect, Drosophila Proteins, Animals, Genetically Modified, RNA Interference, Quantitative Trait Loci, Genome-Wide Association Study, Gene Knockdown Techniques
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