The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Topology, structures, and energy landscapes of human chromosomes
Open accessAbstract
Significance: Various cell types emerge from their nearly identical genetic content for a multicellular organism, in part, via the regulation of the function of the genome—the DNA molecules inside the cell. Similar to the way catalytic activity is lost when proteins denature, the function of the genome is tightly coupled to its 3D organization. A theoretical framework for picturing the structure and dynamics of the genome will therefore greatly advance our understanding of cell biology. We present an energy landscape model of the chromosome that reproduces a diverse set of experimental measurements. The model enables quantitative predictions of chromosome structure and topology and provides mechanistic insight into the role of 3D genome organization in gene regulation and cell differentiation.
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Cites
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S., & Ren, B. (2012) · Nature · doi:10.1038/nature11082 · Cited by 6,829
Funnels, pathways, and the energy landscape of protein folding: A synthesis
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340210302 · Cited by 2,648
Self-citationSingle-cell Hi-C reveals cell-to-cell variability in chromosome structure
Nagano, T., Lubling, Y., Stevens, T. J., Schoenfelder, S., Yaffe, E., Dean, W., Laue, E. D., Tanay, A., & Fraser, P. (2013) · Nature · doi:10.1038/nature12593 · Cited by 1,589
Architectural protein subclasses shape 3D organization of genomes during lineage commitment
Phillips-Cremins, J. E., Sauria, M. E. G., Sanyal, A., Gerasimova, T. I., Lajoie, B. R., Bell, J. S. K., Ong, C.-T., Hookway, T. A., Guo, C., Sun, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.053 · Cited by 1,187
Organization of the mitotic chromosome
Naumova, N., Imakaev, M., Fudenberg, G., Zhan, Y., Lajoie, B. R., Mirny, L. A., & Dekker, J. (2013) · Science · doi:10.1126/science.1236083 · Cited by 976
Complexity of chromatin folding is captured by the strings and binders switch model
Barbieri, M., Chotalia, M., Fraser, J., Lavitas, L.-M., Dostie, J., Pombo, A., & Nicodemi, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204799109 · Cited by 570
Giorgetti, L., Galupa, R., Nora, E. P., Piolot, T., Lam, F., Dekker, J., Tiana, G., & Heard, E. (2014) · Cell · doi:10.1016/j.cell.2014.03.025 · Cited by 460
Cited by
TADs are 3D structural units of higher-order chromosome organization in Drosophila
Szabo, Q., Jost, D., Chang, J.-M., Cattoni, D. I., Papadopoulos, G. L., Bonev, B., Sexton, T., Gurgo, J., Jacquier, C., Nollmann, M., et al. (2018) · Science Advances · doi:10.1126/sciadv.aar8082 · Cited by 282
Inverse statistical problems: from the inverse Ising problem to data science
Nguyen, H. C., Zecchina, R., & Berg, J. (2017) · Advances in Physics · doi:10.1080/00018732.2017.1341604 · Cited by 258
Nonequilibrium physics in biology
Fang, X., Kruse, K., Lu, T., & Wang, J. (2019) · Reviews of Modern Physics · doi:10.1103/revmodphys.91.045004 · Cited by 258
How do cells adapt? stories told in landscapes
Agozzino, L., Balázsi, G., Wang, J., & Dill, K. A. (2020) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-011720-103410 · Cited by 37
Chromatin structures from integrated AI and polymer physics model
Schultz, E. R., Kyhl, S., Willett, R., & de Pablo, J. J. (2025) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1012912 · Cited by 6
Metadata
- Authors
- Zhang, B., & Wolynes, P. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-04-27
- Volume
- 112
- Issue
- 19
- Pages
- 6062-6067
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084861373
- Cited by
- 227
- References
- 7
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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