The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Engineering Escherichia coli coculture systems for the production of biochemical products
Open accessAbstract
Significance: Production of industrial compounds by using engineered microorganisms is a robust method to reduce our reliance on nonrenewable petroleum resources and increase the utility of renewable resources, such as lignocellulose. Because there are major limitations for engineering a single microbial cell to achieve high-yield production, we developed microbial coculture systems consisting of two different microbial cell types to use sugar mixtures that can be derived from lignocellulose efficiently. We demonstrate that this approach is successful for achieving high-level production of two important value-added molecules, cis , cis -muconic acid and 4-hydroxybenzoic acid. This accomplishment establishes a previously unidentified technology for advancing future research in metabolic engineering and synthetic biology.
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Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
Ajikumar, P. K., Xiao, W.-H., Tyo, K. E. J., Wang, Y., Simeon, F., Leonard, E., Mucha, O., Phon, T. H., Pfeifer, B., & Stephanopoulos, G. (2010) · Science · doi:10.1126/science.1191652 · Cited by 1,677
Self-citationSynthetic biology: applications come of age
Khalil, A. S., & Collins, J. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2775 · Cited by 1,373
Herrmann, K. M., & Weaver, L. M. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.473 · Cited by 1,320
Communication in bacteria: an ecological and evolutionary perspective
Keller, L., & Surette, M. G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1383 · Cited by 824
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Lee, J. W., Na, D., Park, J. M., Lee, J., Choi, S., & Lee, S. Y. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.970 · Cited by 735
Zhou, K., Qiao, K., Edgar, S., & Stephanopoulos, G. (2015) · Nature Biotechnology · doi:10.1038/nbt.3095 · Cited by 710
Self-citationMinty, J. J., Singer, M. E., Scholz, S. A., Bae, C.-H., Ahn, J.-H., Foster, C. E., Liao, J. C., & Lin, X. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218447110 · Cited by 467
Natural strategies for the spatial optimization of metabolism in synthetic biology
Agapakis, C. M., Boyle, P. M., & Silver, P. A. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.975 · Cited by 417
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Niu, W., Draths, K. M., & Frost, J. W. (2002) · Biotechnology Progress · doi:10.1021/bp010179x · Cited by 343
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Liew, F., Martin, M. E., Tappel, R. C., Heijstra, B. D., Mihalcea, C., & Köpke, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00694 · Cited by 485
Engineered microbial consortia: strategies and applications
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Weiss, T. L., Young, E. J., & Ducat, D. C. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.10.009 · Cited by 152
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Metadata
- Authors
- Zhang, H., Pereira, B., Li, Z., & Stephanopoulos, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-25
- Volume
- 112
- Issue
- 27
- Pages
- 8266-8271
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1958250075
- Cited by
- 324
- References
- 30
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, H., Pereira, B., Li, Z., & Stephanopoulos, G. (2015). Engineering Escherichia coli coculture systems for the production of biochemical products. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1506781112
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