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Cited by 196Microbial Metabolic Engineering and BioproductionGene Regulatory Network AnalysisBacterial Genetics and Biotechnology

Engineered microbial consortia: strategies and applications

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Duncker, Katherine E., Holmes, Zachary A., You, Lingchong·2021·Microbial Cell Factories
DOI 10.1186/s12934-021-01699-9PMC PMC8597270
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Abstract

Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge because large genetic circuits can be burdensome and difficult to optimize. To overcome these limitations, microbial consortia can be engineered to distribute complex tasks among multiple populations. Recent studies have made substantial progress in programming microbial consortia for both basic understanding and potential applications. Microbial consortia have been designed through diverse strategies, including programming mutualistic interactions, using programmed population control to prevent overgrowth of individual populations, and spatial segregation to reduce competition. Here, we highlight the role of microbial consortia in the advances of metabolic engineering, biofilm production for engineered living materials, biocomputing, and biosensing. Additionally, we discuss the challenges for future research in microbial consortia.

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Cited by

Sorted by citations

Authors
Duncker, K. E., Holmes, Z. A., & You, L.
Affiliations
Duke University (US)
Corresponding author
You, Lingchong
ORCID
Venue
Microbial Cell Factories
Publisher
Springer Science and Business Media LLC
Published
2021-11-16
Volume
20
Issue
1
Pages
211-211
ISSN
1475-2859 (ISSN-L)
DOI
10.1186/s12934-021-01699-9
PMC
PMC8597270
OpenAlex
W3214157624
Cited by
196
References
6
Citations by year
2026: 75 · 2025: 56 · 2024: 34 · 2023: 20 · 2022: 10
FWCI
1.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbial Cell Factories (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science Foundation
  • David and Lucile Packard Foundation
  • National Institutes of Health
  • Office of Naval Research
  • Air Force Office of Scientific Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
microbial consortia, synthetic biology, metabolic engineering, biocomputing, biosensing, biofilm formation, engineered living materials, mutualism, spatial segregation
MeSH terms
Industrial Microbiology, Biosensing Techniques, Biofilms, Synthetic Biology, Microbial Consortia, Metabolic Engineering

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