The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3
Open accessAbstract
Significance: Prostate cancer has an unpredictable natural history: While most tumors are clinically indolent, some patients display lethal phenotypes. Serum prostate-specific antigen is the most often used test in prostate cancer but screening is controversial. Treatment options are limited for metastatic disease, hence the need for early diagnosis. Prostate cancer antigen 3 ( PCA3 ), a long noncoding RNA, is the most specific biomarker identified and approved as a diagnostic test. However, its inherent biological function (if any) has remained elusive. We uncovered a negative transdominant oncogenic role for PCA3 that down-regulates an unrecognized tumor suppressor gene, PRUNE2 (a human homolog of the Drosophila prune gene) thereby promoting malignant cell growth. This work defines a unique biological function for PCA3 in prostate cancer.
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Metadata
- Authors
- Salameh, A., Lee, A. K., Cardó-Vila, M., Nunes, D. N., Efstathiou, E., Staquicini, F. I., Dobroff, A. S., Marchiò, S., Navone, N. M., Hosoya, H., Lauer, R. C., Wen, S., Salmeron, C. C., Hoang, A., Newsham, I., Lima, L. A., Carraro, D. M., Oliviero, S., Kolonin, M. G., Sidman, R. L., Do, K.-A., Troncoso, P., Logothetis, C. J., Brentani, R. R., Calin, G. A., Cavenee, W. K., Dias-Neto, E., Pasqualini, R., & Arap, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-15
- Volume
- 112
- Issue
- 27
- Pages
- 8403-8408
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1499694647
- Cited by
- 277
- References
- 28
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. https://app.cochat.ai/papers/10.1073/pnas.1507882112
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- Salameh, A., Lee, A. K., Cardó-Vila, M., Nunes, D. N., Efstathiou, E., Staquicini, F. I., Dobroff, A. S., Marchiò, S., Navone, N. M., Hosoya, H., Lauer, R. C., Wen, S., Salmeron, C. C., Hoang, A., Newsham, I., Lima, L. A., Carraro, D. M., Oliviero, S., Kolonin, M. G., . . . Arap, W. (2015). PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1507882112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
