The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl
Open accessAbstract
Significance: Reactions of sulfur-centered nucleophiles with nitrogenous species have been studied independently for more than a century for synthetic/industrial purposes; to understand geochemical, atmospheric, and biological processes; and to explain the origins of life. Various products and reaction mechanisms were proposed. We here identify a singular process comprising a network of cascading chemical reactions that form three main bioactive products at physiological pH: nitrosopersulfide, polysulfides, and dinitrososulfite. These anionic products scavenge, transport, and release NO/HNO or sulfide/sulfane sulfur, each displaying distinct chemistries and bioactivities. Our observations provide a chemical foundation for the cross-talk between the NO and H 2 S signaling pathways in biology and suggest that the biological actions of these entities can be neither considered nor studied in isolation.
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Cites
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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
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H 2 S Induces a Suspended Animation-Like State in Mice
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H 2 S: A Universal Defense Against Antibiotics in Bacteria
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Cited by
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Akaike, T., Ida, T., Wei, F.-Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01311-y · Cited by 544
Self-citationTargeting vascular (endothelial) dysfunction
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Metadata
- Authors
- Cortese-Krott, M. M., Kuhnle, G. G. C., Dyson, A., Fernandez, B. O., Grman, M., DuMond, J. F., Barrow, M. P., McLeod, G., Nakagawa, H., Ondrias, K., Nagy, P., King, S. B., Saavedra, J. E., Keefer, L. K., Singer, M., Kelm, M., Butler, A. R., & Feelisch, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-07-29
- Volume
- 112
- Issue
- 34
- Pages
- E4651-60
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2111363155
- Cited by
- 286
- References
- 64
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Cortese-Krott, M. M., Kuhnle, G. G. C., Dyson, A., Fernandez, B. O., Grman, M., DuMond, J. F., Barrow, M. P., McLeod, G., Nakagawa, H., Ondrias, K., Nagy, P., King, S. B., Saavedra, J. E., Keefer, L. K., Singer, M., Kelm, M., Butler, A. R., & Feelisch, M. (2015). Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1509277112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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