Targeting vascular (endothelial) dysfunction

Daiber, Andreas; Steven, Sebastian; Weber, Alina; Shuvaev, Vladimir V.; Muzykantov, Vladimir R.; Laher, Ismail; Li, Huige; Lamas, Santiago; Münzel, Thomas

doi:10.1111/bph.13517

Cited by 501Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors

Targeting vascular (endothelial) dysfunction

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Daiber, Andreas, Steven, Sebastian, Weber, Alina, Shuvaev, Vladimir V., Muzykantov, Vladimir R., Laher, Ismail, Li, Huige, Lamas, Santiago +1 more·2017·British Journal of Pharmacology

DOI 10.1111/bph.13517PMC PMC5446575

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Abstract

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life years, with hypertension a significant risk factor for all causes of death. The endothelium that lines the inner wall of the vasculature regulates essential haemostatic functions, such as vascular tone, circulation of blood cells, inflammation and platelet activity. Endothelial dysfunction is an early predictor of atherosclerosis and future cardiovascular events. We review the prognostic value of obtaining measurements of endothelial function, the clinical techniques for its determination, the mechanisms leading to endothelial dysfunction and the therapeutic treatment of endothelial dysfunction. Since vascular oxidative stress and inflammation are major determinants of endothelial function, we have also addressed current antioxidant and anti‐inflammatory therapies. In the light of recent data that dispute the prognostic value of endothelial function in healthy human cohorts, we also discuss alternative diagnostic parameters such as vascular stiffness index and intima/media thickness ratio. We also suggest that assessing vascular function, including that of smooth muscle and even perivascular adipose tissue, may be an appropriate parameter for clinical investigations. Linked Articles: This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc

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Recent work indicates that normalizing a disease state by direct inhibition of a single source of oxidative stress can be a feasible approach.
“Recent work indicates that this can be a feasible approach (206, 207, 234, 836).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [207]

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Garcia MM, Lima PR, Correia LC (2012). Prognostic value of endothelial function in patients with atherosclerosis: systematic review. Arq Bras Cardiol 99: 857-865.
van den Berg BM, Nieuwdorp M, Stroes ES, Vink H (2006). Glycocalyx and endothelial (dys) function: from mice to men. Pharmacol Rep 58 (Suppl): 75-80. Targeting vascular (endothelial) dysfunction BJP British Journal of Pharmacology (2017) 174 1591-1619 1617 14765381, 2017, 12, · DOI

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Authors: Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T.
Affiliations: Johannes Gutenberg University Mainz (DE)
University of Pennsylvania (US)
University of British Columbia (CA)
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Daiber, Andreas
Münzel, Thomas
ORCID: Daiber, Andreas
Steven, Sebastian
Weber, Alina
Shuvaev, Vladimir V.
Muzykantov, Vladimir R.
Laher, Ismail
Li, Huige
Lamas, Santiago
Münzel, Thomas
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2016-07-04
Volume: 174
Issue: 12
Pages: 1591-1619
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/bph.13517
PMC: PMC5446575
OpenAlex: W2399674801
Cited by: 501
References: 376
Citations by year: 2026: 22 · 2025: 39 · 2024: 53 · 2023: 48 · 2022: 71 · 2021: 69 · 2020: 72 · 2019: 45 · 2018: 30 · 2017: 37 · 2016: 14
FWCI: 7.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Stiftung Mainzer Herz
European Cooperation in Science and Technology (BM1203 EU-ROS, BM1203)
Johannes Gutenberg-Universität Mainz (Stufe 1)
Boehringer Ingelheim Stiftung
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: endothelial dysfunction, vascular dysfunction, endothelial function assessment, oxidative stress, inflammation, antioxidant therapy, anti-inflammatory therapy, vascular stiffness, intima-media thickness, atherosclerosis, hypertension, cardiovascular disease, perivascular adipose tissue, vascular smooth muscle
MeSH terms: Animals, Anti-Inflammatory Agents, Antioxidants, Cardiovascular Diseases, Endothelium, Vascular, Humans, Inflammation, Oxidative Stress

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