The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers
Open accessAbstract
Significance: Although transfer RNAs (tRNAs) are best known as adapter molecules essential for translation, recent biochemical and computational evidence has led to a previously unexpected conceptual consensus that tRNAs are not always end products but can further serve as a source of small functional RNAs. Here we report that a novel type of tRNA-derived small RNA, termed SHOT-RNAs, are specifically and abundantly expressed in sex hormone-dependent breast and prostate cancers. SHOT-RNAs are produced from aminoacylated mature tRNAs by angiogenin-mediated cleavage of the anticodon loop, which is promoted by sex hormones and their receptors. We identified the complete repertoire of SHOT-RNAs, and also found their functional significance in cell proliferation. These results have unveiled a novel tRNA-engaged pathway in tumorigenesis.
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Cited by
A transfer-RNA-derived small RNA regulates ribosome biogenesis
Kim, H. K., Fuchs, G., Wang, S., Wei, W., Zhang, Y., Park, H., Roy-Chaudhuri, B., Li, P., Xu, J., Chu, K., et al. (2017) · Nature · doi:10.1038/nature25005 · Cited by 574
Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)
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Small non-coding RNA and cancer
Romano, G., Veneziano, D., Acunzo, M., & Croce, C. M. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx026 · Cited by 423
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Metadata
- Authors
- Honda, S., Loher, P., Shigematsu, M., Palazzo, J. P., Suzuki, R., Imoto, I., Rigoutsos, I., & Kirino, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-06-29
- Volume
- 112
- Issue
- 29
- Pages
- E3816-25
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1810708914
- Cited by
- 386
- References
- 52
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Honda, S., Loher, P., Shigematsu, M., Palazzo, J. P., Suzuki, R., Imoto, I., Rigoutsos, I., & Kirino, Y. (2015). Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1510077112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
