The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice
Open accessAbstract
Significance: The retina is subject to a variety of insults that lead to degeneration of one or more types of neurons and ultimate visual impairment and blindness. Although the retinas of nonmammalian vertebrates can regenerate new neurons after injury, mammalian retinas largely lack this potential. We have tested whether the expression of the proneural transcription factor Ascl1 may be a key difference between the fish and mouse by targeting this factor to the cells that provide new retinal progenitors in mature retina, the Müller glia. Our results show that at least one of the differences between mammal and fish Müller glia that bears on their difference in regenerative potential is the proneural transcription factor Ascl1.
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Metadata
- Authors
- Ueki, Y., Wilken, M. S., Cox, K. E., Chipman, L., Jorstad, N., Sternhagen, K., Simic, M., Ullom, K., Nakafuku, M., & Reh, T. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-10-19
- Volume
- 112
- Issue
- 44
- Pages
- 13717-13722
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1934209312
- Cited by
- 265
- References
- 35
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Ueki, Y., Wilken, M. S., Cox, K. E., Chipman, L., Jorstad, N., Sternhagen, K., Simic, M., Ullom, K., Nakafuku, M., & Reh, T. A. (2015). Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1510595112
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