The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
In vivo reprogramming of astrocytes to neuroblasts in the adult brain
Open accessAbstract
Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-restricted proliferating precursors in culture; however, this has not been demonstrated in vivo. Here, we show that the single transcription factor SOX2 is sufficient to reprogram resident astrocytes into proliferative neuroblasts in the adult mouse brain. These induced adult neuroblasts (iANBs) persist for months and can be generated even in aged brains. When supplied with BDNF and noggin or when the mice are treated with a histone deacetylase inhibitor, iANBs develop into electrophysiologically mature neurons, which functionally integrate into the local neural network. Our results demonstrate that adult astrocytes exhibit remarkable plasticity in vivo, a feature that might have important implications in regeneration of the central nervous system using endogenous patient-specific glial cells.
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Cited by
Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.001 · Cited by 832
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
Hu, W., Qiu, B., Guan, W., Wang, Q., Wang, M., Li, W., Gao, L., Shen, L., Huang, Y., Xie, G., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.006 · Cited by 484
Pluripotent stem cells in regenerative medicine: challenges and recent progress
Tabar, V., & Studer, L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3563 · Cited by 458
Direct cell reprogramming: approaches, mechanisms and progress
Wang, H., Yang, Y., Liu, J., & Qian, L. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00335-z · Cited by 444
Metadata
- Authors
- Niu, W., Zang, T., Zou, Y., Fang, S., Smith, D. K., Bachoo, R., & Zhang, C.-L.
- Venue
- Nature Cell Biology
- Published
- 2013-09-22
- Volume
- 15
- Issue
- 10
- Pages
- 1164-1175
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1968310639
- Cited by
- 482
- References
- 11
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Niu, W., Zang, T., Zou, Y., Fang, S., Smith, D. K., Bachoo, R., & Zhang, C.-L. (2013). In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nature Cell Biology. https://doi.org/10.1038/ncb2843
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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