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Cited by 194Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applications

Transient decrease in water diffusion observed in human occipital cortex during visual stimulation

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Darquié, Anne, Poline, Jean-Baptiste, Poupon, Cyril, Saint-Jalmes, Hervé, Le Bihan, Denis·2001·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.151125698PMC PMC55431
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Abstract

Using MRI, we report the observation of a transient decrease of the apparent diffusion coefficient (ADC) of water in the human brain visual cortex during activation by a black and white 8-Hz-flickering checkerboard. The ADC decrease was small (<1%), but significant and reproducible, and closely followed the time course of the activation paradigm. Based on the known sensitivity of diffusion MRI to cell size in tissues and on optical imaging studies that have revealed changes in the shape of neurons and glial cells during activation, the observed ADC findings have been tentatively ascribed to a transient swelling of cortical cells. These preliminary results suggest a new approach to produce images of brain activation with MRI from signals directly associated with neuronal activation, and not through changes in local blood flow.

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  • In human visual cortex, diffusion changes preceded the BOLD response and were closely time locked to stimulation.

    “In human visual cortex, these diffusion changes preceded the BOLD response and were closely time locked to stimulation (Darquié et al., 2001; Kohno et al., 2009; Le Bihan et al., 2006).”

    From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Darquié et al., 2001

  • Diffusion MRI was shown to detect brain activation through transient decreases in ADC, suggesting sensitivity to intrinsic microstructural changes in addition to possible vascular effects.

    “A major conceptual shift occurred in the early 2000s when diffusion MRI was shown to detect brain activation through transient decreases in ADC, suggesting sensitivity to intrinsic microstructural changes in addition to possible vascular effects (Fig. 6) (Darquié et al., 2001; Le Bihan et al., 2006).”

    From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Darquié et al., 2001

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Authors
Darquié, A., Poline, J.-B., Poupon, C., Saint-Jalmes, H., & Le Bihan, D.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, 4 Place du Général Leclerc, 91401 Orsay Cedex, France; General Electric Medical Systems Europe, 283 Rue de la Minière, 78553 Buc Cedex, France; and NMR Laboratory, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5012, Domaine Scientifique de la Doua, CPE, 3 Rue Grignard, 69616 Villeurbanne Cedex, France
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2001-07-17
Volume
98
Issue
16
Pages
9391-9395
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.151125698
PMC
PMC55431
OpenAlex
W2051222535
Cited by
194
References
2
Citations by year
2026: 5 · 2025: 11 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 11
FWCI
9.75
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
apparent diffusion coefficient, water diffusion, visual cortex, brain activation, neuronal swelling, cell size, glial cells
MeSH terms
Adult, Diffusion, Female, Humans, Magnetic Resonance Imaging, Male, Occipital Lobe, Photic Stimulation, Water

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