Do dendritic spines twitch?
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Given the high density of synapses, dendrites, and cellular processes in cortex, even subtle activity-related dendritic-spine "twitching" may alter the diffusion environment of water molecules.
“Given the high density of synapses (8 108/mm3), dendrites (400 m/mm3), and cellular processes in cortex (Shapson-Coe et al., 2024), even subtle activity-related dendritic-spine “twitching” (Crick, 1982) may alter the diffusion environment of water molecules (Halpain, 2000; Le Bihan, 2007).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Crick, 1982
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- Authors
- Crick, F.
- Corresponding author
- Crick, Francis
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1982-01
- Volume
- 5
- Pages
- 44-46
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2077476134
- Cited by
- 254
- References
- 12
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 1
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic spines, contractile proteins, synaptic plasticity, neuronal activity, pyramidal neurons, spiny stellate cells
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