Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila
Open accessAbstract
Significance: Inositol phosphate kinase 2 (Ipk2) is a conserved protein that initiates the production of inositol phosphate intracellular messengers that are critical for regulating a variety of cellular processes. Here we explore the developmental roles Ipk2 and its products in Drosophila . We report that Ipk2 kinase activity is required to develop adult body structures including eyes, legs, and wings, which are formed by tissue known as imaginal discs. Although Ipk2 mutant discs seem to pattern normally in embryogenesis, during larval development they fail to undergo normal expansion. We find defects in signaling pathways that control both cell death and proliferation. Our work demonstrates a specific role for Ipk2-produced intracellular messengers in regulating developmental pathways involved in tissue growth and stability.
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Deletion of IPMK results in severe developmental defects across various model organisms.
“The physiological significance of IPMK is highlighted by studies across various model organisms, where its deletion results in severe developmental defects [24,25].”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [24]
Cites
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D. (2000) · Science · doi:10.1126/science.287.5460.2026 · Cited by 394 · see citing works
Self-citationInositol pyrophosphates: between signalling and metabolism
Wilson, M. S. C., Livermore, T. M., & Saiardi, A. (2013) · Biochemical Journal · doi:10.1042/bj20130118 · Cited by 256 · see citing works
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From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
“[24,25,89], neurodegeneration [90,91], small intestinal neuroendocrine tumor [35], angiogenesis and leaky vessels [13], intestinal regeneration [33,34], parasitic and viral infection [92–95], and immunological homeostasis [28,96,97].”
- Authors
- Seeds, A. M., Tsui, M. M., Sunu, C., Spana, E. P., & York, J. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Duke University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-12-08
- Volume
- 112
- Issue
- 51
- Pages
- 15660-15665
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4697392
- OpenAlex
- W2204481459
- Cited by
- 21
- References
- 2
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute (York, Investigator)
- HHS | National Institutes of Health (R01-HL055672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- inositol polyphosphate multikinase, inositol phosphate signaling, imaginal disc development, Drosophila, JAK/STAT signaling, cell proliferation, apoptosis, tissue growth, kinase activity
- MeSH terms
- Animals, Drosophila melanogaster, Transcription Factors, Signal Transduction, Phosphotransferases (Alcohol Group Acceptor), Drosophila Proteins, Cell Proliferation, STAT Transcription Factors, Janus Kinases, Imaginal Discs
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