Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

Guide for the Care and Use of Laboratory Animals: Eighth Edition

(2011) · doi:10.17226/12910 · Cited by 16,199

Developments of a water-maze procedure for studying spatial learning in the rat

Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180

Guide for the care and use of laboratory animals

(1997) · Choice Reviews Online · doi:10.5860/choice.34-3310 · Cited by 2,930

Hsp70 chaperones: Cellular functions and molecular mechanism

Mayer, M. P., & Bukau, B. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4464-6 · Cited by 2,857

Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study

Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932

Molecular Chaperone Functions in Protein Folding and Proteostasis

Kim, Y., Hipp, M. S., Bracher, A., Hayer-Hartl, M. K., & Hartl, F. U. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-092442 · Cited by 1,545

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

Taylor, R. C., & Dillin, A. G. (2013) · Cell · doi:10.1016/j.cell.2013.05.042 · Cited by 585

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

Priller, C., Bauer, T., Mitteregger, G., Krebs, B., Kretzschmar, H. A., & Herms, J. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1450-06.2006 · Cited by 574

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

Kirkegaard, T., Roth, A. G., Petersen, N. H. T., Mahalka, A. K., Olsen, O. D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., et al. (2010) · Nature · doi:10.1038/nature08710 · Cited by 519

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

Lee, S., Hwang, A. B., & Kenyon, C. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.057 · Cited by 495

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549

The aging astrocyte transcriptome from multiple regions of the mouse brain.

Boisvert, M. M., Erikson, G. A., Shokhirev, M. N., & Allen, N. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.039 · Cited by 702

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

Miao, J., Liu, J., Niu, J., Zhang, Y., Shen, W., Luo, C., Liu, Y., Li, C., Li, H., Yang, P., et al. (2019) · Aging Cell · doi:10.1111/acel.13004 · Cited by 284

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

Luo, C., Zhou, S., Zhou, Z., Liu, Y., Yang, L., Liu, J., Zhang, Y., Li, H., Liu, Y., Hou, F. F., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017050574 · Cited by 277

Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases

Singh, M. K., Shin, Y., Ju, S., Han, S., Choe, W., Yoon, K., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084209 · Cited by 256

Amyloid assembly and disassembly

Chuang, E., Hori, A. M., Hesketh, C. D., & Shorter, J. (2018) · Journal of Cell Science · doi:10.1242/jcs.189928 · Cited by 188

Proteostasis collapse is a driver of cell aging and death

Santra, M., Dill, K. A., & de Graff, A. M. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906592116 · Cited by 175

Heat-Shock Proteins in Neuroinflammation

Dukay, B., Csoboz, B., & Tóth, M. E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00920 · Cited by 139

Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer

Morozov, A. V., & Карпов, В. Л. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00761 · Cited by 118

Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging

Wang, M., Pourzand, C., Lei, X., & Zhong, J. L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8135985 · Cited by 103

Cell non-autonomous regulation of health and longevity

Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102

Sex‐specific aging in animals: Perspective and future directions

Bronikowski, A. M., Meisel, R. P., Biga, P. R., Walters, J. R., Mank, J. E., Larschan, E., Wilkinson, G. S., Valenzuela, N., Conard, A. M., de Magalhães, J. P., et al. (2022) · Aging Cell · doi:10.1111/acel.13542 · Cited by 105

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Zatsepina, O. G., Evgen’ev, M. B., & Garbuz, D. G. (2021) · Cells · doi:10.3390/cells10071638 · Cited by 80

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model

Jeremy, M., Gurusubramanian, G., & Roy, V. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-50679-y · Cited by 79

Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies

Ya, J., & Bayraktutan, U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411538 · Cited by 57

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

McLaughlin, T., Falkowski, M., Park, J. W., Keegan, S., Elliott, M. H., Wang, J. J., & Zhang, S. X. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0250-z · Cited by 57

Engineering therapeutic protein disaggregases

Shorter, J. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-10-0693 · Cited by 53

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer’s Disease

Evgen’ev, M. B., Krasnov, G. S., Nesterova, I. V., Garbuz, D. G., Карпов, В. Л., Morozov, A. V., Snezhkina, A. V., Samokhin, A. N., Sergeev, A., Куликов, А. М., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170398 · Cited by 45

Extracellular heat shock proteins in neurodegenerative diseases: New perspectives

Lyon, M. S., & Milligan, C. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134462 · Cited by 49

Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction

Pan, J., Ma, N., Zhong, J., Yu, B., Wan, J., & Zhang, W. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.08.030 · Cited by 43

Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions

Leite, J. S. M., Cruzat, V. F., Krause, M. D. S., & de Bittencourt, P. I. H. (2016) · Nutrire · doi:10.1186/s41110-016-0021-y · Cited by 41

Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70

Morozov, A. V., Astakhova, T. M., Garbuz, D. G., Krasnov, G. S., Bobkova, N. V., Zatsepina, O. G., Карпов, В. Л., & Evgen’ev, M. B. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0792-y · Cited by 39

Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation

Chou, X., Li, X., Min, Z., Ding, F., Ma, K., Shen, Y. L., Sun, D., & Wu, Q. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114098 · Cited by 37

Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway

Zhang, S., Liu, W., Wang, P., Hu, B., Lv, X., Chen, S., Wang, B., & Shao, Z. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04052-1 · Cited by 36

Molecular hallmarks of ageing in amyotrophic lateral sclerosis

Jagaraj, C. J., Shadfar, S., Kashani, S. A., Saravanabavan, S., Farzana, F., & Atkin, J. D. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05164-9 · Cited by 39

Proteostasis and ageing: insights from long‐lived mutant mice

Sands, W. A., Page, M. M., & Selman, C. (2017) · The Journal of Physiology · doi:10.1113/jp274334 · Cited by 32

The Effect of Human HSP70 Administration on a Mouse Model of Alzheimer’s Disease Strongly Depends on Transgenicity and Age

Evgen’ev, M. B., Bobkova, N. V., Krasnov, G. S., Garbuz, D. G., Funikov, S. Y., Kudryavtseva, A. V., Куликов, А. М., Samokhin, A. N., Maltsev, A. V., & Nesterova, I. V. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180987 · Cited by 33

H2S counteracts proinflammatory effects of LPS through modulation of multiple pathways in human cells

Yurinskaya, M. M., Krasnov, G. S., Kulikova, D. A., Zatsepina, O. G., Винокуров, М. Г., Chuvakova, L. N., Rezvykh, A. P., Funikov, S. Y., Morozov, A. V., & Evgen’ev, M. B. (2020) · Inflammation Research · doi:10.1007/s00011-020-01329-x · Cited by 29

Exogenous recombinant Hsp70 mediates neuroprotection after photothrombotic stroke

Demyanenko, S. V., Nikul, V. V., Rodkin, S., Davletshin, A. I., Evgen’ev, M. B., & Garbuz, D. G. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01159-0 · Cited by 29

A Search for Biomarkers of Early-life Stress-related Psychopathology: Focus on 70-kDa Heat Shock Proteins

Solarz, A., Majcher‐Maślanka, I., Kryst, J., & Chocyk, A. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.02.026 · Cited by 27

Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster

Zatsepina, O. G., Nikitina, E. A., Shilova, V. Y., Chuvakova, L. N., Sorokina, S. Y., Vorontsova, Y. E., Tokmacheva, E. V., Funikov, S. Y., Rezvykh, A. P., & Evgen’ev, M. B. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01203-7 · Cited by 29

Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells

Andreeva, N. V., Zatsepina, O. G., Garbuz, D. G., Evgen’ev, M. B., & Belyavsky, A. V. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0691-7 · Cited by 29

Genetic and epigenetic alterations in aging and rejuvenation of human

Park, K., Jeon, M. C., Lee, D., Kim, J., & Im, S.-W. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100137 · Cited by 30

Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice

Acuña-Catalán, D., Shah, S., Wehrfritz, C., Nomura, M., Acevedo, A., Olmos, C., Quiroz, G., Huerta, H., Bons, J., Ampuero, E., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101593 · Cited by 29

The development of modified human Hsp70 (HSPA1A) and its production in the milk of transgenic mice

Gurskiy, Y. G., Garbuz, D. G., Soshnikova, N. V., Краснов, А. Н., Deykin, A. V., Lazarev, V. F., Sverchinsky, D. V., Margulis, B. A., Zatsepina, O. G., Карпов, В. Л., et al. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0729-x · Cited by 24

The Proteasome and Ageing

Hegde, A. N., Duke, L. M., Timm, L. E., & Nobles, H. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_5 · Cited by 25

Small heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration

Kawasaki, F., Koonce, N. L., Guo, L., Fatima, S., Qiu, C., Moon, M. T., Zheng, Y., & Ordway, R. W. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.026385 · Cited by 23

Hsp70 ameliorates sleep deprivation-induced anxiety-like behavior and cognitive impairment in mice

Kang, Z., Lin, Y., Su, C., Li, S., Xie, W., & Wu, X. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110791 · Cited by 22

Chaperones vs. oxidative stress in the pathobiology of ischemic stroke

Soldatov, V. O., Venediktov, A. A., Белых, А. Е., Piavchenko, G. A., Naimzada, M. D., Ogneva, N., Kartashkina, N. L., & Bushueva, O. Y. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1513084 · Cited by 22

Heat shock proteins and cellular senescence in humans: A systematic review

Hebishy, M., Shintouo, C. M., Dufait, I., Debacq‐Chainiaux, F., Bautmans, I., & Njemini, R. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105057 · Cited by 20

Trajectories of cardiovascular ageing—from molecular mechanisms to clinical implementation

Ministrini, S., Wenzl, F. A., Lüscher, T. F., & Camici, G. G. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae178 · Cited by 26

Cell-surface HSP70 associates with thrombomodulin in endothelial cells

Araujo, T. L. S., Venturini, G., Moretti, A. I. S., Tanaka, L. Y., Pereira, A. C., & Laurindo, F. R. M. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-018-00964-y · Cited by 19

The Role of Hsp70 in Adaptation to Adverse Conditions and Its Possible Medical Application

Evgen’ev, M. B., Onikienko, S. B., Chuvakova, L. N., Garbuz, D. G., & Zatsepina, O. G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2802025 · Cited by 19

The development of peptide- and oligonucleotide-based drugs to prevent the formation of abnormal tau in tauopathies

Lozupone, M., Dibello, V., Sardone, R., Castellana, F., Zupo, R., Lampignano, L., Bortone, I., Stallone, R., Altamura, M., Bellomo, A., et al. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2200245 · Cited by 21

Evaluating cytotoxicity of methyl benzoate in vitro

Bunch, H., Park, J., Choe, H., Mostafiz, M. M., Kim, J., & Lee, K. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03351 · Cited by 17

Neuroregeneration: Regulation in Neurodegenerative Diseases and Aging

Бобкова, Н. В., Полтавцева, Р. А., Leonov, S. V., & Sukhikh, G. T. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920140060 · Cited by 17

Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration

Kumar, P., Choudhary, A., Kinger, S., Jagtap, Y. A., Dubey, A. R., Gutti, R. K., Chitkara, D., Suresh, A. K., & Mishra, A. (2023) · Translational Medicine of Aging · doi:10.1016/j.tma.2023.09.001 · Cited by 16

Hsp70 and gama-Semino protein as possible prognostic marker of prostate cancer

Mishra, M. K. (2018) · Frontiers in bioscience · doi:10.2741/4684 · Cited by 16

Beneficial effect of ER stress preconditioning in protection against FFA-induced adipocyte inflammation via XBP1 in 3T3-L1 adipocytes

Wang, M., Chen, X., Zheng, Z., Yu, S., Zhou, B., Liu, Y., Liu, D., Chen, Y., & Qian, X. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03627-3 · Cited by 16

Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model

Ribeiro, C. T., Peixoto, D. O., Santos¹, L. F. D. S., Girardi, C. S., Brum, P. O., Kessler, F. G. C., Somensi, N., Behrens, L. M. P., Bittencourt, R. R., Soares, L. S., et al. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100253 · Cited by 18

Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNFα in human phagocytes

Yurinskaya, M. M., Kochetkova, O. Y., Shabarchina, L. I., O.Yu., A., Сусликов, А. В., Евгеньев, М. Б., & Vinokurov, M. G. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0743-z · Cited by 16

Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Kwon, H. J., Kim, W., Jung, H. Y., Kang, M. S., Kim, J. W., Hahn, K. R., Yoo, D. Y., Yoon, Y. S., Hwang, I. K., & Kim, D. W. (2019) · Laboratory Animal Research · doi:10.1186/s42826-019-0020-2 · Cited by 15

From Small Peptides to Large Proteins against Alzheimer’sDisease

Picone, P., Sanfilippo, T., Vasto, S., Baldassano, S., Guggino, R., Nuzzo, D., Bulone, D., Biagio, P. L. S., Muscolino, E., Monastero, R., et al. (2022) · Biomolecules · doi:10.3390/biom12101344 · Cited by 16

A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng)

Liu, Q.-X., Zhang, W., Wang, J., Hou, W., & Wang, Y. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.04.006 · Cited by 15

Interferon-γ-Induced Mesenchymal Stem Cell Exosomes Attenuate Chondrocyte Senescence and Osteoarthritis Progression by Hsp70

Liu, S., Mou, J., Zhu, X., Liu, J., Du, C., Zhu, Z., Tan, J., Cheng, S., Qiu, X., Huang, W. Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c12590 · Cited by 14

Autophagy and Hsp70 activation alleviate oral epithelial cell death induced by food-derived hypertonicity

Yang, J. H., Zhang, H., Sun, S., Wang, X., Guan, Y., Mi, Q.-L., Zeng, W., Xiang, H., Zhu, H., Zou, X. G., et al. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01068-2 · Cited by 14

Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice

Tytell, M., Davis, A., Giles, J. M., Snider, L. C., Xiao, R., Dozier, S., Presley, T. D., & Kavanagh, K. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0835-4 · Cited by 14

Aging, cancer, and autophagy: connections and therapeutic perspectives

Zapatería, B., & Arias, E. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1516789 · Cited by 13

Hippocampal region-specific endogenous neuroprotection as an approach in the search for new neuroprotective strategies in ischemic stroke. Fiction or fact?

Beresewicz, M. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105455 · Cited by 12

Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol

Tan, J. K., Jaafar, F., & Makpol, S. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2383-6 · Cited by 12

Preexposure to heat stress attenuates sepsis-associated inflammation and cognitive decline in rats

Jiang, S., Bai, L., Zhang, X., Zhou, X., & Liu, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136647 · Cited by 12

Whole-body pulsed EMF stimulation improves cognitive and psychomotor activity in senescent rats

Téglás, T., Dörnyei, G., Bretz, K., & Nyakas, C. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.036 · Cited by 11

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model

Jeremy, M., Gurusubramanian, G., & Roy, V. K. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23280 · Cited by 11

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy

Bhatia, T. N., Clark, R. N., Needham, P. G., Miner, K. M., Jamenis, A. S., Eckhoff, E. A., Abraham, N., Hu, X., Wipf, P., Luk, K. C., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01114-6 · Cited by 10

Handelin Reduces Ultraviolet A-Induced Photoaging by Inhibiting Reactive Oxygen Species Generation and Enhancing Autophagy

Duan, Y., Xiang, Y., Chu, J., Lin, X., He, M., Zhang, C., Sun, S., & Ling, H. (2022) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2022.j108 · Cited by 9

Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia‐induced cognitive dysfunction in aged mice

Xie, Y., Huang, J., & Chen, Y. (2022) · Brain and Behavior · doi:10.1002/brb3.2861 · Cited by 9

Cell-Permeable HSP70 Protects Neurons and Astrocytes Against Cell Death in the Rotenone-Induced and Familial Models of Parkinson’s Disease

Vinokurov, A. Y., Palalov, A. A., Kritskaya, K. A., Demyanenko, S. V., Garbuz, D. G., Evgen’ev, M. B., Esteras, N., & Abramov, A. Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04077-9 · Cited by 9

Epigenetic reprogramming for ocular aging and disease: Mechanisms, biomarkers, and the road to the clinic

Lee, J., Han, M., Wang, K., Butler, L. R., & Sinclair, D. A. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101442 · Cited by 7

Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency

Bakar, Z. H. A., Damanhuri, H. A., Makpol, S., Aizat, W. M., Sani, N. F. A., Hamzah, A. I. Z. A., Aripin, K. N. N., Rani, M. D. M., Noh, N. A., Razali, R., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180511 · Cited by 8

Heat-shock protein 70 (HSP70) polymorphisms affect the risk of coke-oven emission-induced neurobehavioral damage

Tian, F., Li, W., Lyu, Y., Zhang, P., Mu, J., Pei, Q.-L., & Zheng, J. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.11.003 · Cited by 7

Heat shock proteins: a history of study in Russia

Евгеньев, М. Б. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01219-z · Cited by 7

Morphofunctional features in mice treated by low and high Hsp70 doses

Piavchenko, G. A., Venediktov, A. A., Kuzmin, E. A., & Kuznetsov, S. L. (2023) · Sechenov Medical Journal · doi:10.47093/2218-7332.2023.918.13 · Cited by 7

Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity

Tarbox, H. E., Branch, A., & Fried, S. D. (2025) · Science Advances · doi:10.1126/sciadv.adt3778 · Cited by 8

Heat shock proteins (Hsp70 and Hsp90) in neurodegeneration: pathogenic roles and therapeutic potential

Khalaf, N. B. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1711422 · Cited by 7

Cyclin‐dependent kinase Pho85p and its cyclins are involved in replicative lifespan through multiple pathways in yeast

Nakajima, T., Maruhashi, T., Morimatsu, T., & Mukai, Y. (2019) · FEBS Letters · doi:10.1002/1873-3468.13707 · Cited by 6

A short-lived fish with long-lasting effects: hallmarks of aging in Nothobranchius furzeri

Savel, O., Lehmann, J., Poyraz, Y. K., & Page, M. M. (2026) · Frontiers in Aging · doi:10.3389/fragi.2025.1741819 · Cited by 7

Heat-shock protein HSP70 decreases activity of proteasomes in human neuroblastoma cells treated by amyloid-beta 1-42 with isomerized Asp7

Morozov, A. V., Yurinskaya, M. M., Mitkevich, V. A., Garbuz, D. G., Преображенская, О. В., Винокуров, М. Г., Evgen’ev, M. B., Карпов, В. Л., & Makarov, A. А. (2017) · Molecular Biology · doi:10.1134/s0026893316060133 · Cited by 5

Exogenous Hsp70 attenuates nitroglycerin-induced migraine-like symptoms in mice

Wu, F., Huang, Y., Wei, G., Huang, Z., Shi, C., Lin, W., & Liao, J. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00314.2021 · Cited by 5

Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia

Alway, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00026-9 · Cited by 6

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Silva, R. A., Sarigol, F., Karagöz, G. E., Osmanagic‐Myers, S., & Foisner, R. (2025) · Life Science Alliance · doi:10.26508/lsa.202503485 · Cited by 4

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