The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Precision glycocalyx editing as a strategy for cancer immunotherapy
Open accessAbstract
Significance: Successful tumors are able to evade the immune system, which is otherwise capable of killing transformed cells. Therapies that prevent this evasion have become revolutionary treatments for incurable cancers. One mechanism of evasion is the presentation of sugars, called sialic acids, within the cell surface’s sugar coating, or glycocalyx. Here, we designed biotherapeutic molecules, termed “antibody–enzyme conjugates,” that selectively remove sialic acids from tumor cells. The antibody directs the enzyme to the cancer cells, the enzyme cleaves the sugars, and then the antibody directs immune cells to kill the desialylated cancer cells. The conjugate increased tumor cell killing compared with the antibody alone. Editing the cancer cell glycocalyx with an antibody–enzyme conjugate represents a promising approach to cancer immune therapy.
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Cites
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Cited by
Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?
Mereiter, S., Balmaña, M., Campos, D., Gomes, J., & Reis, C. A. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.06.006 · Cited by 565
The tumour glyco-code as a novel immune checkpoint for immunotherapy
RodrÍguez, E., Schetters, S. T. T., & van Kooyk, Y. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2018.3 · Cited by 473
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
Pluvinage, J. V., Haney, M. S., Smith, B. A. H., Sun, J., Iram, T., Bonanno, L., Li, L., Lee, D. P., Morgens, D. W., Yang, A. C., et al. (2019) · Nature · doi:10.1038/s41586-019-1088-4 · Cited by 459
Self-citationSiglecs as Immune Cell Checkpoints in Disease
Duan, S., & Paulson, J. C. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102419-035900 · Cited by 452
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD
Kudelka, M. R., Stowell, S. R., Cummings, R. D., & Neish, A. S. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0331-7 · Cited by 355
Metadata
- Authors
- Xiao, H., Woods, E. C., Vukojicic, P., & Bertozzi, C. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-08-22
- Volume
- 113
- Issue
- 37
- Pages
- 10304-10309
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2508974650
- Cited by
- 440
- References
- 48
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiao, H., Woods, E. C., Vukojicic, P., & Bertozzi, C. R. (2016). Precision glycocalyx editing as a strategy for cancer immunotherapy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1608069113
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
