The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
Open accessAbstract
BACKGROUND/AIMS: We investigated if mixtures of the phosphatidylcholine (PC) lipids 1,2-dilauroyl-sn-glycero-3-phosphocholine (C12:0 PC; DLPC) and 1,2-diarachidoyl-sn-glycero-3-phosphocholine (C20:0 PC; DAPC), which differ by eight methylene groups in acyl chain length, lead to the spontaneous formation of distinct lipid rafts and asymmetric bilayers. METHODS: The experiments were performed using Atomic Force Microscopy (AFM). RESULTS: We show that DLPC and DAPC mixed at a molar ratio of 1:1 lead to the formation of single, double and triple bilayers with peaks at 6.14 ± 0.11, 13.27 ± 0.17 and 20.54 ± 0.46 nm, respectively (n=750). Within these formations discrete height steps of 0.92 nm can be resolved (n=422). CONCLUSION: The most frequently observed height steps value of 0.92 nm matches best with the calculated mean lipid hydrophobic thickness difference for asymmetric C12:0 PC and C20:0 PC lipid bilayers of 0.88 nm. This indicates the ability of DLPC and DAPC to form asymmetric lipid bilayers.
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Lee, A. G. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00056-7 · Cited by 886
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Metadata
- Authors
- Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R.
- Venue
- Cellular Physiology and Biochemistry
- Publisher
- S. Karger AG
- Published
- 2013
- Volume
- 32
- Issue
- 1
- Pages
- 46-52
- ISSN
- 1015-8987 (ISSN-L)
- 1421-9778
- OpenAlex
- W2021882008
- Cited by
- 3,923
- References
- 2
- FWCI
- 116.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. (2013). Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains. Cellular Physiology and Biochemistry. https://doi.org/10.1159/000350122
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