The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury
Open accessAbstract
Significance: Autophagy maintains cellular homoeostasis by bulk or selective degradation of cytoplasmic components including organelles or protein aggregates. Its role in axon regeneration remains speculative. Here, we found that boosting autophagy stabilized microtubules by degrading a microtubule destabilizing protein, SCG10 (superior cervical ganglia protein 10), in cultured CNS neurons and promoted axon growth. Furthermore, treatment with a specific autophagy-inducing peptide, Tat-beclin1, attenuated axon retraction, promoted axon regeneration, and improved locomotor functional recovery in mice with spinal cord injury. This study reveals a critical role of autophagy in stabilizing neuronal microtubules and a promising therapeutic effect of an autophagy-inducing reagent on CNS axons following injury.
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Cites
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Self-citationHow to Interpret LC3 Immunoblotting
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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Identification of a candidate therapeutic autophagy-inducing peptide
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PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
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“Accumulating evidence suggests that MTs play important roles in the regulation of autophagosome formation and transportation in axons (33, 64).”
BackgroundKomatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614
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Cited by
Rong, Y., Liu, W., Wang, J., Fan, J., Luo, Y., Li, L., Kong, F., Chen, J., Tang, P., & Cai, W. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1571-8 · Cited by 333
Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis
Feng, S.-Q., Yao, X., Zhang, Y., Hao, J., Duan, H.-Q., Zhao, C.-X., Sun, C., Li, B., Fan, B.-Y., Wang, X., et al. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.245480 · Cited by 298
Programmed cell death in spinal cord injury pathogenesis and therapy
Shi, Z., Yuan, S., Shi, L., Li, J., Ning, G., Kong, X., & Feng, S. (2021) · Cell Proliferation · doi:10.1111/cpr.12992 · Cited by 293
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182
Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
Petrova, V., Nieuwenhuis, B., Fawcett, J. W., & Eva, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041798 · Cited by 32
Metadata
- Authors
- He, M., Ding, Y., Chu, C., Tang, J., Xiao, Q., & Luo, Z.-G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-09-16
- Volume
- 113
- Issue
- 40
- Pages
- 11324-11329
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2520485831
- Cited by
- 177
- References
- 15
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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- He, M., Ding, Y., Chu, C., Tang, J., Xiao, Q., & Luo, Z.-G. (2016). Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1611282113
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