Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

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Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

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Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

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Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways

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Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedPreprint

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Gli1can rescue the in vivo function ofGli2

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Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

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Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

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Hair cycle regulation of Hedgehog signal reception

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A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor

Zhang, Q. H., Zhang, L., Wang, B., Ou, C.-Y., Chien, C., & Jiang, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.05.004 · Cited by 225 · see citing works

Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

Wang, C., Pan, Y., & Wang, B. (2010) · Development · doi:10.1242/dev.052126 · Cited by 212 · see citing works

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

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Brachydactyly

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A Novel Protein-processing Domain in Gli2 and Gli3 Differentially Blocks Complete Protein Degradation by the Proteasome

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Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

Zhang, Q., Shi, Q., Chen, Y., Yue, T., Li, S., Wang, B., & Jiang, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912008106 · Cited by 149 · see citing works

Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase

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Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

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The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

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Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

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Impaired endochondral bone development and osteopenia in Gli2-deficient mice

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Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination

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The Xt J allele generates a Gli 3 fusion transcript

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PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

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Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper Output of Hedgehog Signaling

Schwend, T., Jin, Z., Jiang, K., Mitchell, B. J., Jia, J., & Yang, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.512962 · Cited by 21 · see citing works

Suppressor of Fused (Sufu) Mediates the Effect of Parathyroid Hormone-like Hormone (Pthlh) on Chondrocyte Differentiation in the Growth Plate

Hsu, S.-H. C., Zhang, X., Cheng, S. Y., Wunder, J. S., Hui, C., & Alman, B. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382275 · Cited by 16 · see citing works

Immunohistochemistry and RNA In Situ Hybridization in Mouse Brain Development

Liu, J., & Liu, A. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-655-9_18 · Cited by 6 · see citing works

Hedgehog signaling: mechanisms and evolution

Ye, X., & Liu, A. (2011) · Frontiers in Biology · doi:10.1007/s11515-011-1146-2 · Cited by 2 · see citing works

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Zhu, S., Chen, W., Masson, A., & Li, Y. (2024) · Cell Discovery · doi:10.1038/s41421-024-00689-6 · Cited by 513 · see citing works

Gli Proteins: Regulation in Development and Cancer

Niewiadomski, P., Niedziółka, S. M., Markiewicz, Ł., Uśpieński, T., Baran, B., & Chojnowska, K. (2019) · Cells · doi:10.3390/cells8020147 · Cited by 175 · see citing works

Hedgehog Signal and Genetic Disorders

Sasai, N., Toriyama, M., & Kondo, T. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01103 · Cited by 141 · see citing works

Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action

Ohba, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186665 · Cited by 117 · see citing works

A catalog of single nucleotide changes distinguishing modern humans from archaic hominins

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Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy

Aliabadi, F., Sohrabi, B., Mostafavi, E., Pazoki–Toroudi, H., & Webster, T. J. (2021) · Open Biology · doi:10.1098/rsob.200390 · Cited by 100 · see citing works

Dimerization quality control ensures neuronal development and survival

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Functional analysis of Cullin 3 E3 ligases in tumorigenesis

Cheng, J., Guo, J., Wang, Z. P., North, B. J., Tao, K., Dai, X., & Wei, W. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.11.001 · Cited by 80 · see citing works

Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

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Dietary nutraceuticals as backbone for bone health

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SPOP and cancer: a systematic review.

Clark, A. D., & Burleson, M. O. (2020) · PubMed Central · Cited by 71 · see citing works

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

Guillamot, M., Ouazia, D., Dolgalev, I., Yeung, S. T., Kourtis, N., Dai, Y., Corrigan, K., Zea-Redondo, L., Saraf, A., Florens, L. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0454-6 · Cited by 70 · see citing works

Deregulation of SPOP in Cancer

Zhang, H., Jin, X., & Huang, H. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-2801 · Cited by 65 · see citing works

Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats

Li, W., Shi, Z., Jing, H., Dou, Y., Liu, X., Zhang, M., Qiu, Z., Heger, Z., & Li, N. (2025) · Nature Communications · doi:10.1038/s41467-025-59725-y · Cited by 51 · see citing works

Proteostasis in the Hedgehog signaling pathway

Liu, A. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.10.009 · Cited by 50 · see citing works

Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals

Yung, T. M., Poon, F., Liang, M., Coquenlorge, S., McGaugh, E. C., Hui, C., Wilson, M. D., Nostro, M. C., & Kim, T.-H. (2019) · Nature Communications · doi:10.1038/s41467-019-12624-5 · Cited by 44 · see citing works

Regulation of Hedgehog signaling Offers A Novel Perspective for Bone Homeostasis Disorder Treatment

Lv, W.-T., Du, D., Gao, R., Yu, C. W., Jia, Y., Jia, Z., & Wang, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163981 · Cited by 45 · see citing works

Hedgehog Signaling in Gonadal Development and Function

Dilower, I., Niloy, A. J., Kumar, V., Kothari, A., Lee, E. B., & Rumi, M. A. K. (2023) · Cells · doi:10.3390/cells12030358 · Cited by 40 · see citing works

Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions

Michelacci, Y. M., Baccarin, R., & Rodrigues, N. N. P. (2023) · Life · doi:10.3390/life13071460 · Cited by 45 · see citing works

Circadian BMAL1 regulates mandibular condyle development by hedgehog pathway

Yu, S., Tang, Q., Xie, M., Zhou, X., Long, Y., Xie, Y., Guo, F., & Chen, L. (2019) · Cell Proliferation · doi:10.1111/cpr.12727 · Cited by 39 · see citing works

GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis

Coquenlorge, S., Yin, W.-C., Yung, T. M., Pan, J., Zhang, X., Mo, R., Belik, J., Hui, C., & Kim, T.-H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.016 · Cited by 37 · see citing works

A combination of genome-wide association study and selection signature analysis dissects the genetic architecture underlying bone traits in chickens

Li, Y. D., Liu, X., Li, Z., Wang, W. J., Li, Y. M., Cao, Z. P., Luan, P., Xiao, F., Gao, H., Guo, H., et al. (2021) · animal · doi:10.1016/j.animal.2021.100322 · Cited by 36 · see citing works

E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation

Shen, J., Fu, B., Li, Y., Wu, Y., Sang, H., Zhang, H., Lin, H., Liu, H., & Huang, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.706395 · Cited by 35 · see citing works

Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord

Cai, H., & Liu, A. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.04.002 · Cited by 30 · see citing works

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

Hu, Z., Chen, B., & Zhao, Q. (2019) · Biology Open · doi:10.1242/bio.040840 · Cited by 29 · see citing works

SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts

Sun, J., Shin, D. Y., Eiseman, M., Yallowitz, A. R., Li, N., Lalani, S., Li, Z., Cung, M., Bok, S., Debnath, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24819-w · Cited by 29 · see citing works

Novel insights into the SPOP E3 ubiquitin ligase: From the regulation of molecular mechanisms to tumorigenesis

Li, X.-M., Wu, H., Xia, Q., Zhou, P., Wang, S., Xiao, Y., & Hu, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112882 · Cited by 29 · see citing works

Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing

Shao, J., Li, H., Zhang, X., Zhang, X., Li, Z.-Z., Jiao, G., & Sun, G. (2020) · Current Medical Science · doi:10.1007/s11596-020-2306-x · Cited by 28 · see citing works

GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer

Burleson, M. O., Deng, J., Qin, T., Duong, T. M., Yan, Y., Gu, X. Q., Das, D., Easley, A., Liss, M. A., Yew, P. R., et al. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0108 · Cited by 26 · see citing works

The role of E3 ubiquitin ligases in bone homeostasis and related diseases

Dong, Y., Chen, Y., Ma, G., & Cao, H. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.06.016 · Cited by 26 · see citing works

Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination

Zhang, Q., & Jiang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413338 · Cited by 23 · see citing works

SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors

Umberger, P. A., & Ogden, S. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.710295 · Cited by 22 · see citing works

The inhibitory roles of Ihh downregulation on chondrocyte growth and differentiation

Deng, A., Zhang, H., Hu, M., Liu, S., Wang, Y., Gao, Q., & Guo, C. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5458 · Cited by 21 · see citing works

Differential Regulation of Hedgehog and Parathyroid Signaling in Mulberry and Nonmulberry Silk Fibroin Textile Braids

Midha, S., Chawla, S., Chakraborty, J., Chameettachal, S., & Ghosh, S. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00874 · Cited by 21 · see citing works

Hedgehog pathway, cell cycle, and primary cilium

Zhuang, T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02605-7 · Cited by 17 · see citing works

SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic Implications

Yang, X., & Zhu, Q. (2022) · Genes · doi:10.3390/genes13112051 · Cited by 16 · see citing works

SPOP Targets Oncogenic Protein ZBTB3 for Destruction to Suppress Endometrial CancerPreprint

Jin, X., Wang, J., Li, Q., Zhuang, H., Yang, J., Lin, Z.-H., Lin, T., Lv, Z., Shen, L., Yan, C., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3491871 · Cited by 16 · see citing works

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity

Tawaratsumida, K., Redecke, V., Wu, R., Kuriakose, J. A., Bouchard, J. J., Mittag, T., Lohman, B. K., Mishra, A., High, A. A., & Häcker, H. (2022) · Science Advances · doi:10.1126/sciadv.abq0084 · Cited by 17 · see citing works

SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis

Tan, P., Wang, A., Chen, H., Du, Y., Qian, B., Shi, H., Zhang, Y., Xia, X., & Fu, W. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111606 · Cited by 15 · see citing works

Gli promotes tumor progression through regulating epithelial-mesenchymal transition in non–small-cell lung cancer

Jiang, L., Huang, J., Hu, Y., Lu, P., Luo, Q., & Wang, L. (2020) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-020-1049-x · Cited by 15 · see citing works

Hedgehog Signalling in Osteogenesis and Bone Metabolism: Molecular Mechanisms, Regulatory Networks and Implications for Skeletal Disease

Njie, R., Xu, S., Wu, T., Pi, J., Lin, S., Zhang, P., Wang, J., Dai, Q., Shen, H., Zhang, N., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70813 · Cited by 12 · see citing works

SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.

Yuan, D., Chen, Y., Yang, Z., Li, G., Wu, M., Jiang, J., Li, D., & Yu, Q. (2020) · PubMed Central · Cited by 12 · see citing works

Uterine function in the mouse requires speckle-type poz protein†

Hai, L., Szwarc, M. M., He, B., Lonard, D. M., Kommagani, R., DeMayo, F. J., & Lydon, J. P. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy060 · Cited by 9 · see citing works

E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting

Ong, J. Y., & Torres, J. Z. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82883 · Cited by 8 · see citing works

SPOPL induces tumorigenicity and stemness in glioma stem cells by activating Notch signaling

Hu, T., Xuan, R., Han, E., Cai, L., & Xia, Z. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04394-4 · Cited by 7 · see citing works

Regulatory mechanisms governing GLI proteins in hedgehog signaling

Yoshida, S., & Yoshida, K. (2024) · Anatomical Science International · doi:10.1007/s12565-024-00814-1 · Cited by 6 · see citing works

Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma

Beadle, E. P., Bennett, N. E., & Rhoades, J. A. (2023) · Cancers · doi:10.3390/cancers15133360 · Cited by 5 · see citing works

The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury

Deng, C., Xu, L., Zhang, Y., Zhao, L., Linghu, Y., & Yu, Y. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-021-02287-8 · Cited by 5 · see citing works

TMEM132A regulates mouse hindgut morphogenesis and caudal development

Zeng, H., & Liu, A. (2023) · Development · doi:10.1242/dev.201630 · Cited by 5 · see citing works

Chicken speckle-type POZ protein (SPOP) negatively regulates MyD88/NF-κB signaling pathway mediated proinflammatory cytokine production to promote the replication of Newcastle disease virus

Meng, Z., Wang, Y., Kong, X., Cen, M., & Duan, Z. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103461 · Cited by 4 · see citing works

Regulation of Stem Cells by Cullin-RING Ligase

Fu, L., Cui, C., & Zhang, L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_6 · Cited by 4 · see citing works

Cul3 substrate adaptor SPOP targets Nup153 for degradation

Ong, J. Y., Abdusamad, M., Ramírez, I., Gholkar, A. A., Zhang, X., Gimeno, T. V., & Torres, J. Z. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-04-0198 · Cited by 3 · see citing works

Association of SPOP Expression with the Immune Response to Salmonella Infection in Chickens

Wang, F., Li, Q., Wang, Q., Zheng, M., Wen, J., & Zhao, G. (2020) · Animals · doi:10.3390/ani10020307 · Cited by 3 · see citing works

Restraint upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction between Quasi-Static Load and the mTOR Pathway

Caetano-Silva, S. P., Simbi, B. H., Marr, N., Hibbert, A. P., Allen, S., & Pitsillides, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413220 · Cited by 3 · see citing works

[Effect of superparamagnetic iron oxide on differentiation of rat bone marrow stem cells into chondrocytes in vitro].

Jiang, F., Xiao, J., Lu, Y.-T., Li, W., Duan, Y.-W., Sheng, Z., & Li, S. (2017) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2017.05.14 · Cited by 3 · see citing works

Effects of Improper Mechanical Force on the Production of Sonic Hedgehog, RANKL, and IL-6 in Human Periodontal Ligament Cells In Vitro

Yamashita, E., Negishi, S., Kikuta, J., Shimizu, M., & Senpuku, H. (2024) · Dentistry Journal · doi:10.3390/dj12040108 · Cited by 2 · see citing works

High-throughput screening identifies a critical role of the SPOP–PABPC1 axis in lung adenocarcinoma progression

Zhang, J., Liu, R., Han, X., Jiao, Y., Peng, Y., Zhou, Z., Deng, Y., & Gong, L. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2602470123 · Cited by 2 · see citing works

The synergistic link between sonic hedgehog signaling pathway and gut–lung axis: Its influential role toward chronic obstructive pulmonary disease progression

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Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split‐Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study

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