Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5

The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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Roles of N-Linked Glycans in the Endoplasmic Reticulum

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Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Mutant p53: one name, many proteinsPreprint

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When mutants gain new powers: News from the mutant p53 field

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

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Complex N-Glycan Number and Degree of Branching Cooperate to Regulate Cell Proliferation and Differentiation

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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

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Mutant p53 drives invasion by promoting integrin recycling

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A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

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Mutant p53 Gain-of-Function in CancerPreprint

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

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Transcriptional Regulation by P53

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Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family

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Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

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Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM

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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

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Translating p53 into the clinic

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Integrin β 1 -focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

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Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

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A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

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p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

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A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

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Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

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The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

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Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

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Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasionPreprint

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Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cellsPreprint

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Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

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Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In Vivo

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Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

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Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

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Identification of GRO1 as a Critical Determinant for Mutant p53 Gain of Function

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Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

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Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

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ATP Consumption Promotes Cancer Metabolism

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Ectonucleoside Triphosphate Diphosphohydrolase Type 5 (Entpd5)-Deficient Mice Develop Progressive Hepatopathy, Hepatocellular Tumors, and Spermatogenic Arrest

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Endoplasmic Reticulum Quality Control Is Involved in the Mechanism of Endoglin-Mediated Hereditary Haemorrhagic Telangiectasia

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Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

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Mutant p53 and chromatin regulation

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Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter

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Migratory Activity of CD105+ Pancreatic Cancer Cells Is Strongly Enhanced by Pancreatic Stellate Cells

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Mutant p53 as a guardian of the cancer cell

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The p53 Pathway in Glioblastoma

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Mutant p53 partners in crime

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Tumor hypoxia and radiotherapy: A major driver of resistance even for novel radiotherapy modalities

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Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis

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Mutant p53 on the Path to Metastasis

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How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

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MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

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Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms

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Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6

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The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer

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Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression

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p53’s Extended Reach: The Mutant p53 Secretome

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Context is everything: extrinsic signalling and gain-of-function p53 mutants

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Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma

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Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells

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Development of a Fully Cross-Validated Bayesian Network Approach for Local Control Prediction in Lung Cancer

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RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment

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Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity

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Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression

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Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives

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ST6GalNAc‐I promotes lung cancer metastasis by altering MUC5AC sialylation

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Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis

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The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer

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Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN Status

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Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma

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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

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The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

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Complexes formed by mutant p53 and their roles in breast cancer

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Host tp53 mutation induces gut dysbiosis eliciting inflammation through disturbed sialic acid metabolism

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The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation

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Mutant p53 regulates Survivin to foster lung metastasisPreprint

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Biomarkers of tumor invasiveness in proteomics (Review)

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A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors

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Transition of amyloid/mutant p53 from tumor suppressor to an oncogene and therapeutic approaches to ameliorate metastasis and cancer stemness

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Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

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Amplifying Tumor–Stroma Communication: An Emerging Oncogenic Function of Mutant p53

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p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance

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Comprehensive Evaluation of Multiple Approaches Targeting ABCB1 to Resensitize Docetaxel-Resistant Prostate Cancer Cell Lines

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Wild-type and mutant p53 in cancer-related ferroptosis. A matter of stress management?

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From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy

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Control of Nucleotide Metabolism Enables Mutant p53’s Oncogenic Gain-of-Function Activity

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Cancer Stem Cells: Emergent Nature of Tumor Emergency

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The concomitant use of USP28 and p53 to predict the progression of urothelial carcinoma of the bladder

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Gene Regulation by p53 in Human Cancer System

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Transcriptional regulation of metabolism in disease: From transcription factors to epigenetics

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p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding

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PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

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Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression

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Ternary Copper (II) Complex Induced Apoptosis and Cell Cycle Arrest in Colorectal Cancer Cells

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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties

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Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

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MGAT4A/Galectin9‐Driven N ‐Glycosylation Aberration as a Promoting Mechanism for Poor Prognosis of Endometrial Cancer with TP53 Mutation

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Identifying small molecule probes of ENTPD5 through high throughput screening

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Expression of TMEM16A in Colorectal Cancer and Its Correlation With Clinical and Pathological Parameters

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Pro-metastatic p53 mutants control folding of N-glycoproteins

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Uracil as a biomarker for spatial pyrimidine metabolism in the development of gingivobuccal oral squamous cell carcinoma

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Mutant p53 and ELK1 co‐drive FRA ‐1 expression to induce metastasis in breast cancer

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A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage

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TGF-β1 Facilitates TAp63α Protein Lysosomal Degradation to Promote Pancreatic Cancer Cell Migration

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Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Immunoautophagy-Related Genes and Tumor Microenvironment

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FUCA1: An Underexplored p53 Target Gene Linking Glycosylation and Cancer Progression

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ENTPD5: identification of splicing variants and their impact on cancer survival

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Metabolic Stress Adaptations Underlie Mammary Gland Morphogenesis and Breast Cancer Progression

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Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis

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Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells

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Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats

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A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells

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p53‑p72‑Δ225‑331‑V31I identified in a cholangiocarcinoma cell line promotes migration and invasiveness via the downregulation of claudin‑1 expression and the activation of Cdc42

Puetkasichonpasutha, J., & Suthiphongchai, T. (2020) · Oncology Reports · doi:10.3892/or.2020.7827 · Cited by 5 · see citing works

[ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].

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Meta-analysis and in-silico functional characterization of the SNCA variant rs356220 in Parkinson’s disease

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2-(4-Benzyloxy-3-methoxyphenyl)-5-(carbethoxyethylene)-7-methoxy-benzofuran, a Benzofuran Derivative, Suppresses Metastasis Effects in P53-Mutant Hepatocellular Carcinoma Cells

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Label-Free Biosensors for Early Diagnosis of Cancer Based on G-Quadruplex and Isothermal Amplification

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Genetic Screening Approaches to Cancer Driver Characterization and Synthetic Lethal Target Discovery

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Analysis of tumor protein p53 expression levels in different stages of breast cancer

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Yin and Yang of Pluripotency: Results of Analysis of Genes Overexpressed In Tumor-Initiating Cells of Krebs-2 Ascites Carcinoma

Efremov, Y. R., Proskurina, A. S., Potter, E. A., Долгова, Е. В., Efremova, O. V., Kolchanov, N. A., & Bogachev, S. S. (2019) · Mathematical Biology and Bioinformatics · doi:10.17537/2019.14.160 · Cited by 1 · see citing works

Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases

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Systematic pan-cancer analysis reveals the prognostic and immunological roles of ectonucleoside triphosphate diphosphohydrolase 6

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Synthesis of 3-carbethoxy-4(3’-chloro-4’-hydroxy) phenyl-but-3-en-2-one and its cytotoxicity evaluation against cancer cell carrying mutant p53

Julianus, J., Mustofa, M., & Jumina, J. (2021) · Indonesian Journal of Pharmacology and Therapy · doi:10.22146/ijpther.1211

Generation of a New Model for RB1-deficient Pineoblastoma and Lysosome-based Therapy

Chung, E. D. (2019) · TSpace (University of Toronto)

ENTPD5 splice variants: novel players in cancer?

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Mutant p53 and ELK-1 co-drive the expression of FRA-1 in breast cancer cellsPreprint

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Na+/K+-ATPase-associated FXYD3 Protein As An Intracellular Therapeutic Target in CancerPreprint

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Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion

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Matrix metalloproteinases, chemoresistance and cancer

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Additional file 5 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930431

Additional file 2 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930422

Additional file 1 of Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Merle, N., Elmshäuser, S., Strassheimer, F., Wanzel, M., König, A. M., Funk, J. S., Neumann, M., Kochhan, K., Helmprobst, F., Pagenstecher, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21268889

Additional file 6 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930434

Additional file 4 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930428

Additional file 2 of Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Merle, N., Elmshäuser, S., Strassheimer, F., Wanzel, M., König, A. M., Funk, J. S., Neumann, M., Kochhan, K., Helmprobst, F., Pagenstecher, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21268892

Additional file 1 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930419

Additional file 3 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930425

Additional file 7 of Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

Pavlakis, E., Neumann, M., Merle, N., Wieboldt, R., Wanzel, M., Ponath, V., von Strandmann, E. P., Elmshäuser, S., & Stiewe, T. (2023) · Figshare · doi:10.6084/m9.figshare.23930437

Purinergic signal transduction and metabolic regulation by ENTPD5 and ENTPD6

Qi, Y., Li, X., Song, X., Wei, W., Ghiran, I. C., & Robson, S. C. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1680378

Secreted luciferases as a minimally invasive 3R-compliant tool for accurate monitoring of tumor burden

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Effet de l’inactivation du gène suppresseur de tumeur p53 et de sa réactivation pharmacologique sur la réponse cytotoxique anti-tumorale

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Chromatin folding and function

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p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding

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Mutant p53 promotes tumor progression by the endoplasmic reticulum UDPase ENTPD5

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Mutant p53-ENTPD5 control of the calnexin/calreticulin cycle: a druggable target for inhibiting integrin-α5-driven metastasis

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The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN

Shen, Z. (2011)

Identification and validation of ENTPD5 as a novel target gene of mutant p53 in cancer

Vogiatzi, F. (2016)