The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
Open accessAbstract
Chronic hypoxia causes pulmonary hypertension with smooth muscle cell proliferation and matrix deposition in the wall of the pulmonary arterioles. We demonstrate here that hypoxia also induces a pronounced inflammation in the lung before the structural changes of the vessel wall. The proinflammatory action of hypoxia is mediated by the induction of distinct cytokines and chemokines and is independent of tumor necrosis factor-α signaling. We have previously proposed a crucial role for heme oxygenase-1 (HO-1) in protecting cardiomyocytes from hypoxic stress, and potent anti-inflammatory properties of HO-1 have been reported in models of tissue injury. We thus established transgenic mice that constitutively express HO-1 in the lung and exposed them to chronic hypoxia. HO-1 transgenic mice were protected from the development of both pulmonary inflammation as well as hypertension and vessel wall hypertrophy induced by hypoxia. Significantly, the hypoxic induction of proinflammatory cytokines and chemokines was suppressed in HO-1 transgenic mice. Our findings suggest an important protective function of enzymatic products of HO-1 activity as inhibitors of hypoxia-induced vasoconstrictive and proinflammatory pathways.
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Cites
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X. F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,498
Mccoubrey, W. K., Huang, T. J., & Maines, M. D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00725.x · Cited by 823
Humbert, M., Monti, G., Brenot, F., Sitbon, O., Portier, A., Grangeot-Keros, L., Duroux, P., Galanaud, P., Simonneau, G., & Emilie, D. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.5.7735624 · Cited by 797
Tuder, R. M., Groves, B. Μ., Badesch, D. B., & Voelkel, N. F. (1994) · PubMed Central · Cited by 784
Pulmonary Hypertension in Severe Acute Respiratory Failure
Zapol, W. M., & Snider, M. T. (1977) · New England Journal of Medicine · doi:10.1056/nejm197703032960903 · Cited by 740
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
Morita, T., Perrella, M. A., Lee, M. E., & Kourembanas, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1475 · Cited by 707
Self-citationExpression of heme oxygenase-1 can determine cardiac xenograft survival
Soares, M. P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S. T., Colvin, R. B., Choi, A. M., Poss, K. D., et al. (1998) · Nature Medicine · doi:10.1038/2063 · Cited by 612
Cited by
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Self-citationThe Immunology of Macrophage Activation Syndrome
Crayne, C. B., Albeituni, S., Nichols, K. E., & Cron, R. Q. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00119 · Cited by 633
Different Faces of the Heme-Heme Oxygenase System in Inflammation
Wagener, F. A. D. T. G., Volk, H.-D., Willis, D., Abraham, N. G., Soares, M. P., Adema, G. J., & Figdor, C. G. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.5 · Cited by 537
Self-citationHeme Oxygenase-1: The “Emerging Molecule” Has Arrived
Morse, D., & Choi, A. M. K. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4862 · Cited by 532
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Metadata
- Authors
- Minamino, T., Christou, H., Hsieh, C.-M., Liu, Y., Dhawan, V., Abraham, N. G., Perrella, M. A., Mitsialis, S. A., & Kourembanas, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-10
- Volume
- 98
- Issue
- 15
- Pages
- 8798-8803
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988205788
- Cited by
- 366
- References
- 34
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Minamino, T., Christou, H., Hsieh, C.-M., Liu, Y., Dhawan, V., Abraham, N. G., Perrella, M. A., Mitsialis, S. A., & Kourembanas, S. (2001). Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.161272598
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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