The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Arid5a exacerbates IFN-γ-mediated septic shock by stabilizing T-bet mRNA
Abstract
Significance: Septic shock is one of the major causes of morbidity and mortality throughout the world. Despite extensive efforts, septic shock remains a major medical challenge. In this study, using Arid5a-deficient mice, we demonstrated a critical role of this protein in lipopolysaccharide (LPS)-induced shock through regulation of IFN-γ expression in T cells by preventing the mRNA degradation of its major transcription factor T-bet. Further, we identified the conserved stem loop structure at 3′UTR of T-bet mRNA required for binding Arid5a during its action. Our study indicates the therapeutic potential of anti-agonistic agents for Arid5a in the prevention of pathological conditions of septic shock.
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“Mice lacking Arid5a (Arid5a−/−) exhibit impaired IL-6 and IFN-γ expression and are resistant to LPS-induced endotoxin shock (Masuda et al., 2013; Zaman et al., 2016”
From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Zaman et al., 2016
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T-bet: a bridge between innate and adaptive immunity
Lazarevic, V., Glimcher, L. H., & Lord, G. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3536 · Cited by 486 · cited 5×
“T-bet dysregulation has been associated with several Th1-driven immunopathological disorders, suggesting that regulation of T-bet is essential to control the innate immunity (9, 10).”
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Research works printed but not linked: 23
- 10.1146/annurev-pathol-011110-130327 · DOI
- 10.1146/annurev.iy.11.040193.003035 · DOI
- FP Heinzel, The role of IFN-gamma in the pathology of experimental endotoxemia. J Immunol 145, 2920–2924 (1990). · DOI
- 10.1084/jem.179.5.1437 · DOI
- 10.1097/SHK.0b013e31802b5d9f · DOI
- 10.1002/eji.200737295 · DOI
- 10.1016/S0092-8674(00)80702-3 · DOI · Paper page
- 10.1126/science.1065543 · DOI · Paper page
- 10.1038/ni.2059 · DOI
- 10.1073/pnas.1307419110 · DOI · Paper page
- 10.1084/jem.20151289 · DOI · Paper page
- 10.1189/jlb.0912437 · DOI
- 10.1177/09680519010070030101 · DOI
- 10.1093/intimm/dxp122 · DOI
- 10.1038/382171a0 · DOI
- 10.1073/pnas.92.16.7307 · DOI
- 10.1093/nar/gki145 · DOI
- 10.1038/ni1584 · DOI · Paper page
- 10.1128/iai.65.11.4734-4737.1997 · DOI
- 10.1128/JVI.79.20.12798-12806.2005 · DOI
- 10.4049/jimmunol.175.7.4603 · DOI
- 10.1016/j.cell.2013.04.034 · DOI · Paper page
- 10.1097/SHK.0b013e31816e2cda · DOI
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Targeting Interleukin-6 Signaling in Clinic
Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.026 · Cited by 904
Self-citationHistorical overview of the interleukin-6 family cytokine
Kang, S., Narazaki, M., Metwally, H., & Kishimoto, T. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190347 · Cited by 360
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Metadata
- Authors
- Zaman, M. M.-U., Masuda, K., Nyati, K. K., Dubey, P. K., Ripley, B., Wang, K., Chalise, J. P., Higa, M., Hanieh, H., & Kishimoto, T.
- Affiliations
- Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;
- Biological Sciences Department, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-09-26
- Volume
- 113
- Issue
- 41
- Pages
- 11543-11548
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 56
- References
- 1
- Language
- en
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