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Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA

Masuda, Kazuya, Ripley, Barry, Nyati, Kishan Kumar, Dubey, Praveen Kumar, Zaman, Mohammad Mahabub-Uz, Hanieh, Hamza, Higa, Mitsuru, Yamashita, Kazuo, Standley, Daron M., Mashima, Tsukasa, Katahira, Masato, Okamoto, Toru, Matsuura, Yoshiharu, Takeuchi, Osamu, Kishimoto, Tadamitsu·2016·Journal of Experimental Medicine
DOI 10.1084/jem.20151289PMC PMC4821647
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Abstract

Balance in signal transducer and activator of transcription (STAT) activation is a key factor in regulating the fate of naive CD4+ T cells. Here, we demonstrate that AT-rich interactive domain-containing protein 5a (Arid5a) in T cells directs naive CD4+ T cells to differentiate into inflammatory CD4+ T cells, especially Th17 cells, through selective stabilization of Stat3 (but not Stat1 and Stat5) mRNA in an IL-6–dependent manner. Loss of Arid5a in T cells led to reduction of STAT3 level under Th17-polarizing conditions, whereas STAT1 and STAT5 in Arid5a-deficient T cells were highly activated compared with those of WT T cells under the same conditions. These cells displayed the feature of antiinflammatory (Il10-expressing) CD4+ T cells. Thus, we show a T cell–intrinsic role of Arid5a on fate decisions of naive CD4+ T cells through selective stabilization of Stat3 mRNA.

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Metadata

Authors
Masuda, K., Ripley, B., Nyati, K. K., Dubey, P. K., Zaman, M. M.-U., Hanieh, H., Higa, M., Yamashita, K., Standley, D. M., Mashima, T., Katahira, M., Okamoto, T., Matsuura, Y., Takeuchi, O., & Kishimoto, T.
Affiliations
  • Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan 1
  • Biological Sciences Department, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia 3
  • Laboratory of System Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan 2
  • Structural Energy Bioscience Research Section, Institute of Advanced Energy, Kyoto University, Kyoto 611-0011, Japan 4
  • Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan 5
  • Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan 6
Venue
Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2016-03-28
Volume
213
Issue
4
Pages
605-619
ISSN
  • 0022-1007
  • 1540-9538
DOI
10.1084/jem.20151289
PMC
PMC4821647
Cited by
88
References
5
Language
en
Funders
  • Japan Society for the Promotion of Science (26860328)
  • Japanese Science and Technology Agency
  • Japanese Ministry of Education, Culture, Sports, Science and Technology

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