The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection
Open accessAbstract
Significance: A highly effective malaria vaccine capable of long-term protection against genetically diverse strains is urgently needed. Here, we demonstrate that a three-dose regimen of a live attenuated whole-parasite malaria vaccine conferred durable sterile protection through 33 weeks in ∼50% of subjects against a controlled human malaria infection strain that is heterologous to the vaccine strain. Prior studies by others and us have shown that T cells are critical to mediating sterile protection after live-attenuated malaria vaccination. Here, we provide evidence that this Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine) induces antigen-specific IFN-γ-producing CD8 and CD4 T cells that recognize both the homologous and the heterologous Pf strain.
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Cites
Global malaria mortality between 1980 and 2010: a systematic analysis
Murray, C. J., Rosenfeld, L. C., Lim, S. S., Andrews, K. G., Foreman, K. J., Haring, D., Fullman, N., Naghavi, M., Lozano, R., & Lopez, A. D. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60034-8 · Cited by 1,452
Stoute, J. A., Slaoui, M., Heppner, D. G., Momin, P., Kester, K. E., Desmons, P., Wellde, B. T., Garçon, N., Krzych, U., Marchand, M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701093360202 · Cited by 870
Cited by
Malaria Vaccines: Recent Advances and New Horizons
Draper, S. J., Sack, B. K., King, C. R., Nielsen, C. M., Rayner, J. C., Higgins, M. K., Long, C. A., & Seder, R. A. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.008 · Cited by 331
Self-citationKisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4512 · Cited by 293
Self-citationOwalla, T. J., Hergott, D. E. B., Seilie, A. M., Staubus, W., Chavtur, C., Chang, M., Kublin, J. G., Egwang, T. G., & Murphy, S. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1003452 · Cited by 9
Metadata
- Authors
- Lyke, K. E., Ishizuka, A. S., Berry, A. A., Chakravarty, S., DeZure, A., Enama, M. E., James, E. R., Billingsley, P. F., Gunasekera, A., Manoj, A., Li, M., Ruben, A. J., Li, T., Eappen, A. G., Stafford, R. E., KC, N., Murshedkar, T., Mendoza, F. H., Gordon, I. J., Zephir, K. L., Holman, L. A., Plummer, S. H., Hendel, C. S., Novik, L., Costner, P. J. M., Saunders, J. G., Berkowitz, N. M., Flynn, B. J., Nason, M. C., Garver, L. S., Laurens, M. B., Plowe, C. V., Richie, T. L., Graham, B. S., Roederer, M., Sim, B. K. L., Ledgerwood, J. E., Hoffman, S. L., & Seder, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-02-21
- Volume
- 114
- Issue
- 10
- Pages
- 2711-2716
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2591439676
- Cited by
- 243
- References
- 2
- FWCI
- 29.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyke, K. E., Ishizuka, A. S., Berry, A. A., Chakravarty, S., DeZure, A., Enama, M. E., James, E. R., Billingsley, P. F., Gunasekera, A., Manoj, A., Li, M., Ruben, A. J., Li, T., Eappen, A. G., Stafford, R. E., KC, N., Murshedkar, T., Mendoza, F. H., Gordon, I. J., . . . Seder, R. A. (2017). Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1615324114
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
