The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Malaria Vaccines: Recent Advances and New Horizons
Open accessAbstract
The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection.
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Cites
Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei
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Self-citationProtection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
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Self-citationBasigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
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Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8 + T Cell Immunity
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Self-citationLiver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
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“These cells rely on CXCR6 and CD69 to maintain long-term positioning in the liver where they can patrol the sinusoids and respond rapidly to infection (Fernandez-Ruiz et al., 2016; Tse et al., 2014).”
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Cited by
Peptide-Based Vaccines: Current Progress and Future Challenges
Malonis, R. J., Lai, J. R., & Vergnolle, O. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00472 · Cited by 602
T cell-mediated immunity to malaria
Kurup, S. P., Butler, N. S., & Harty, J. T. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0158-z · Cited by 242
Ko, K.-T., Lennartz, F., Mekhaiel, D., Guloglu, B., Marini, A., Deuker, D. J., Long, C. A., Jore, M. M., Miura, K., Biswas, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33379-6 · Cited by 32
Self-citationKing, L. D. W., Pulido, D., Barrett, J. R., Davies, H., Quinkert, D., Lias, A. M., Silk, S. E., Pattinson, D. J., Diouf, A., Williams, B. G., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101654 · Cited by 27
Self-citationOgieuhi, I. J., Ajekiigbe, V. O., Kolo-Manma, K., Akingbola, A., Odeniyi, T. A., Soyemi, T. S., Ayomide, J. H., Thiyagarajan, B., & Awolola, B. D. (2024) · Discover Public Health · doi:10.1186/s12982-024-00284-w · Cited by 13
Metadata
- Authors
- Draper, S. J., Sack, B. K., King, C. R., Nielsen, C. M., Rayner, J. C., Higgins, M. K., Long, C. A., & Seder, R. A.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 24
- Issue
- 1
- Pages
- 43-56
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2825109425
- Cited by
- 331
- References
- 104
- FWCI
- 34.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Draper, S. J., Sack, B. K., King, C. R., Nielsen, C. M., Rayner, J. C., Higgins, M. K., Long, C. A., & Seder, R. A. (2018). Malaria Vaccines: Recent Advances and New Horizons. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2018.06.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
