Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
Open accessAbstract
Significance: Neurotrophic factors are endogenous survival factors for developing neurons during their programmed cell death, and represent therapeutic candidates in several neurodegenerative diseases. Studies in the developing spinal cord suggest that neurotrophic factors promote the survival of motor neurons in a combinatorial manner. To better understand this, we systematically assayed pairwise combinations of neurotrophic factors (NTFs) on highly standardized motor neuron cultures prepared by a unique FACS technique. Our data unravel potent additivity of three neurotrophic factors due to their specific survival effects on distinct classes of motor neurons innervating different targets. Further analyses are required to better understand combinatorial NTF effects in adulthood and to define optimized NTF combinations for degenerative motor neuron diseases.
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The motoneuron family includes alpha motoneurons (MNa) with relatively higher levels of Poln and Spp134, gamma motoneurons (MNg) with relatively higher levels of Esrrg and Htr1f, and preganglionic cells (PGC) expressing Gfra3, Nos1, and Fbn2.
“The motoneuron (MN) family includes alpha motoneurons (MNa) which had relatively higher levels of Poln and Spp134, gamma motoneurons (MNg) which had relatively higher levels of Esrrg and Htr1f35, and the related preganglionic cells (PGC) which expressed Gfra3, Nos1, and Fbn236,37.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [36]
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- Authors
- Schaller, S., Buttigieg, D., Alory, A., Jacquier, A., Barad, M., Merchant, M., Gentien, D., de la Grange, P., & Haase, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Centre d'Immunologie de Marseille-Luminy (CIML), CNRS, INSERM, Aix-Marseille University, 13288 Marseille, France;
- Genentech (US)
- Université Paris Sciences et Lettres (FR)
- GenoSplice Technology, Institut du Cerveau et de la Moëlle (ICM), Hôpital Pitié Salpêtrière, 75013 Paris, France
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-03-07
- Volume
- 114
- Issue
- 12
- Pages
- E2486-E2493
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5373341
- OpenAlex
- W2593514003
- Cited by
- 34
- References
- 46
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 1 · 2017: 3
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- neurotrophic factors, motor neuron survival, hepatocyte growth factor, ciliary neurotrophic factor, artemin, c-Met, GFRα3, syndecan-3, combinatorial screening
- MeSH terms
- Amyotrophic Lateral Sclerosis, Animals, Cell Survival, Female, Flow Cytometry, Humans, Mice, Inbred C57BL, Mice, Transgenic, Motor Neurons, Nerve Tissue Proteins, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Ciliary Neurotrophic Factor, Glial Cell Line-Derived Neurotrophic Factor Receptors, Mice, Syndecan-3, Ciliary Neurotrophic Factor Receptor alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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