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Human and rat gut microbiome composition is maintained following sleep restriction
Open accessAbstract
Significance: It is widely presumed that there is a relationship between sleep and the gut microbiome because both sleep restriction and dysbiosis of the gut microbiome are associated with metabolic diseases such as obesity and diabetes. Here, we report sleep restriction over several consecutive days does not overtly influence the composition of the microbiome of either rats or humans, despite both species showing other changes associated with sleep loss. These analyses suggest that sleep loss and microbial dysbiosis have independent effects on the development of metabolic diseases.
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“some studies reported a loss of association after adjustment for interfering factors (602), or did not detect a significant association between indices of sleep disturbances and CRP”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [602]
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Metadata
- Authors
- Zhang, S. L., Bai, L., Goel, N., Bailey, A., Jang, C. J., Bushman, F. D., Meerlo, P., Dinges, D. F., & Sehgal, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Pennsylvania (US)
- University of Groningen (NL)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-08
- Volume
- 114
- Issue
- 8
- Pages
- E1564-E1571
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5338418
- OpenAlex
- W2586552311
- Semantic Scholar
- 0f4c0871629e2f2802bd6e70905efdaad3e80b8a
- Cited by
- 139
- References
- 50
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 18 · 2023: 22 · 2022: 23 · 2021: 18 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 6
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute (R25MH060490)
- HHS | NIH | National Institute of Neurological Disorders and Stroke (T32HL07713)
- Children's Hospital of Philadelphia (P30 AI 045008)
- DOD | Office of Naval Research (N00014-11-1-0361)
- National Aeronautics and Space Administration (NNX14AN49G)
- HHS | NIH | National Institute of Nursing Research (R01 NR004281)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- gut microbiota, sleep restriction, insufficient sleep, microbiota composition, cross-species comparison, rats, human, 16S rRNA, operational taxonomic units, metabolic disorders
- MeSH terms
- Gastrointestinal Microbiome, Adult, Animals, Cognition, DNA, Bacterial, Feces, Female, Humans, Male, Metabolic Diseases, Middle Aged, RNA, Ribosomal, 16S, Sleep Deprivation, Rats, Sprague-Dawley, Genes, rRNA, Gastrointestinal Tract, Rats, Healthy Volunteers, Dysbiosis
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