The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling
Open accessAbstract
Social bees harbor a simple and specialized microbiota that is spatially organized into different gut compartments. Recent results on the potential involvement of bee gut communities in pathogen protection and nutritional function have drawn attention to the impact of the microbiota on bee health. However, the contributions of gut microbiota to host physiology have yet to be investigated. Here we show that the gut microbiota promotes weight gain of both whole body and the gut in individual honey bees. This effect is likely mediated by changes in host vitellogenin, insulin signaling, and gustatory response. We found that microbial metabolism markedly reduces gut pH and redox potential through the production of short-chain fatty acids and that the bacteria adjacent to the gut wall form an oxygen gradient within the intestine. The short-chain fatty acid profile contributed by dominant gut species was confirmed in vitro. Furthermore, metabolomic analyses revealed that the gut community has striking impacts on the metabolic profiles of the gut compartments and the hemolymph, suggesting that gut bacteria degrade plant polymers from pollen and that the resulting metabolites contribute to host nutrition. Our results demonstrate how microbial metabolism affects bee growth, hormonal signaling, behavior, and gut physicochemical conditions. These findings indicate that the bee gut microbiota has basic roles similar to those found in some other animals and thus provides a model in studies of host-microbe interactions.
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“Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects [106,107,108].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [108]
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Metadata
- Authors
- Zheng, H., Powell, J. E., Steele, M. I., Dietrich, C., & Moran, N. A.
- Affiliations
- The University of Texas at Austin (US)
- Siemens Healthineers (Germany) (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-04-18
- Volume
- 114
- Issue
- 18
- Pages
- 4775-4780
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5422775
- OpenAlex
- W2605691951
- Cited by
- 664
- References
- 85
- Citations by year
- 2026: 63 · 2025: 75 · 2024: 91 · 2023: 74 · 2022: 91 · 2021: 83 · 2020: 74 · 2019: 45 · 2018: 59 · 2017: 9
- FWCI
- 47.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (1R01-GM108477-01)
- DOD | Defense Advanced Research Projects Agency (HR0011-15-C-0095)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Pesticide Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Arachnid Ecology and Behavior
- Keywords
- honey bee gut microbiota, short-chain fatty acids, gut pH, redox potential, oxygen gradients, insulin signaling, vitellogenin, gustatory response, host-microbe interactions, bee nutrition
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Bees, Body Weight, Insect Hormones, Signal Transduction
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