The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
NLR network mediates immunity to diverse plant pathogens
Open accessAbstract
Significance: Plant and animal nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins often function in pairs to mediate innate immunity to pathogens. However, the degree to which NLR proteins form signaling networks beyond genetically linked pairs is poorly understood. In this study, we discovered that a large NLR immune signaling network with a complex genetic architecture confers immunity to oomycetes, bacteria, viruses, nematodes, and insects. The network emerged over 100 Mya from a linked NLR pair that diversified into up to one-half of the NLRs of asterid plants. We propose that this NLR network increases robustness of immune signaling to counteract rapidly evolving plant pathogens.
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Cites
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Cited by
Thirty years of resistance: Zig-zag through the plant immune system
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Reconstitution and structure of a plant NLR resistosome conferring immunity
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The plant immune system: From discovery to deployment
Jones, J. D. G., Staskawicz, B. J., & Dangl, J. L. (2024) · Cell · doi:10.1016/j.cell.2024.03.045 · Cited by 544
A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors
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Diverse NLR immune receptors activate defence via the RPW 8‐NLR NRG 1
Castel, B., Ngou, P., Cevik, V., Redkar, A., Kim, D., Yang, Y., Ding, P., & Jones, J. D. G. (2019) · New Phytologist · doi:10.1111/nph.15659 · Cited by 267
Metadata
- Authors
- Wu, C.-H., Abd-El-Haliem, A., Bozkurt, T. O., Belhaj, K., Terauchi, R., Vossen, J. H., & Kamoun, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-07-11
- Volume
- 114
- Issue
- 30
- Pages
- 8113-8118
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2736049245
- Cited by
- 462
- References
- 49
- FWCI
- 35.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, C.-H., Abd-El-Haliem, A., Bozkurt, T. O., Belhaj, K., Terauchi, R., Vossen, J. H., & Kamoun, S. (2017). NLR network mediates immunity to diverse plant pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1702041114
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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